Beermann B, Groschinsky-Grind M, Lindstrom B
Eur J Clin Pharmacol. 1977 Mar 11;11(3):203-5. doi: 10.1007/BF00606411.
Eight healthy volunteers received hydro-chlorothiazide 75 mg as Dichlotride and Esiderx. Maximal plasma levels were significantly (p less than 0.05) higher after Dichlotride than Esidrex, 512 +- 189 and 376 +- 70ng/ml, respectively. However, the bioavailability of the two brands of hydrochlorothiazide did not differ significantly as judged by comparison of the AUC0 leads to 9h and AUC0 leads to chi, and the urinary recovery of hydrochlorothiazide during 48 hrs.
八名健康志愿者服用了75毫克氢氯噻嗪，分别为双氢氯噻嗪片（Dichlotride）和依西太尔（Esiderx）。服用双氢氯噻嗪片后的最大血浆浓度显著（p<0.05）高于依西太尔，分别为512±189纳克/毫升和376±70纳克/毫升。然而，通过比较0至9小时的曲线下面积（AUC0→9h）、0至无穷大的曲线下面积（AUC0→∞）以及48小时内氢氯噻嗪的尿回收率判断，这两种品牌的氢氯噻嗪生物利用度无显著差异。
