碱式碳酸铝凝胶与氢氧化镁凝胶相互作用对酸中和的影响。
Effect of interaction of aluminum hydroxycarbonate gel and magnesium hydroxide gel on acid neutralization.
作者信息
Vanderlaan R K, White J L, Hem S L
出版信息
J Pharm Sci. 1979 Dec;68(12):1498-501. doi: 10.1002/jps.2600681209.
Acid neutralization by mixtures of aluminum hydroxycarbonate gel and magnesium hydroxide gel differs from the sum of the acid neutralization of each gel. Acid neutralization by magnesium hydroxide gel in the mixture is not observed until after a substantial portion of the aluminum hydroxycarbonate gel has reacted with acid, even though magnesium hydroxide gel is the faster reacting of the two gels. It is hypothesized that amorphous aluminum hydroxycarbonate forms a coating on the crystalline magnesium hydroxide particles due to electrostatic attraction. This coating prevents protons from reaching the highly reactive magnesium hydroxide until the coating is dissolved by the acid neutralization of aluminum hydroxycarbonate.
碱式碳酸铝凝胶和氢氧化镁凝胶混合物的酸中和作用不同于每种凝胶酸中和作用的总和。在混合物中，直到相当一部分碱式碳酸铝凝胶与酸发生反应后，才会观察到氢氧化镁凝胶的酸中和作用，尽管氢氧化镁凝胶是两种凝胶中反应较快的一种。据推测，无定形碱式碳酸铝由于静电吸引在结晶氢氧化镁颗粒上形成一层涂层。在该涂层被碱式碳酸铝的酸中和作用溶解之前，该涂层会阻止质子接触高活性的氢氧化镁。
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