含铝和镁抗酸化合物的特性。II. 共干燥粉末。

Characterization of antacid compounds containing both aluminum and magnesium. II. Codried powders.

作者信息

Peterson C L, Perry D L, Masood H, White J L, Hem S L, Fritsch C, Haeusler F

机构信息

Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana 47907.

出版信息

Pharm Res. 1993 Jul;10(7):1005-7. doi: 10.1023/a:1018910705853.

DOI:10.1023/a:1018910705853

PMID:8378241

Abstract

The composition and antacid properties of six samples of codried antacids containing both aluminum and magnesium were determined. Aluminum hydroxide-magnesium carbonate codried gel and aluminum hydroxide-magnesium hydroxide codried gel were non-homogeneous, as the samples contained combinations of hydrotalcite, amorphous aluminum hydroxide, magnesium hydroxide, magnesium hydroxycarbonate, and magnesium carbonate. All samples passed the preliminary antacid test and had high acid neutralizing capacities. However, the rate of acid neutralization varied between samples. In some cases the rate of acid neutralization at a dose of 400 mg was too slow to raise the pH to 3.0 as required by the Rossett-Rice test.

摘要

对六个同时含有铝和镁的共干燥抗酸剂样品的成分和抗酸特性进行了测定。氢氧化铝 - 碳酸镁共干燥凝胶和氢氧化铝 - 氢氧化镁共干燥凝胶是非均匀的，因为样品中含有水滑石、无定形氢氧化铝、氢氧化镁、碱式碳酸镁和碳酸镁的组合。所有样品均通过了初步抗酸测试，且具有高酸中和能力。然而，不同样品之间的酸中和速率有所不同。在某些情况下，400毫克剂量的酸中和速率过慢，无法按照罗塞特 - 赖斯试验的要求将pH值提高到3.0。