Malone D N, Drever J C, Grant I W, Percy-Robb I W
Br Med J. 1972 Jul 22;3(5820):202-5. doi: 10.1136/bmj.3.5820.202.
The hypothalamo-pituitary-adrenal axis has been assessed in 17 asthmatic children before and after long-term prednisolone therapy was changed to daily corticotrophin. In 14 of the 17 children the plasma corticosteroid concentration exceeded 15 mug/100 ml within five days of starting corticotrophin. No exacerbation of asthmatic symptoms occurred during conversion. The plasma corticosteroid response to insulin-induced hypoglycaemia was normal in four children about six weeks after conversion to corticotrophin, took up to 36 months to become normal in nine, and remained abnormal in one child throughout the period of the trial.
对17名哮喘儿童在长期泼尼松龙治疗改为每日促肾上腺皮质激素治疗前后的下丘脑 - 垂体 - 肾上腺轴进行了评估。17名儿童中有14名在开始促肾上腺皮质激素治疗的五天内血浆皮质类固醇浓度超过15微克/100毫升。转换过程中未出现哮喘症状加重。转换为促肾上腺皮质激素治疗约六周后，4名儿童对胰岛素诱导的低血糖的血浆皮质类固醇反应正常，9名儿童需要长达36个月才恢复正常，1名儿童在整个试验期间反应仍异常。
