Ferenczy A, Bertrand G, Gelfand M M
Am J Obstet Gynecol. 1979 Apr 15;133(8):859-67. doi: 10.1016/0002-9378(79)90302-8.
A radioautographic analysis of the number and distribution of labeled nuclei after in vitro incorporation of radiothymidine was carried out in human endometrium during the normal menstrual cycle. The highest rates of proliferation were recorded on cycle days 8 to 10 in the upper one third of the functionalis layer. Coinciding with intraglandular secretory activity on cycle day 19, the rate of proliferation of gland cells decreased near zero levels and remained unchanged thereafter. Midsecretory phase arteriolar coiling and stromal predecidualization were associated with increased isotope incorporation. DNA synthesis in premenstrual endometrium was limited to the surface epithelium, predecidua, and vascular endothelium. The endometrium of the isthmus and cornual regions and of the basalis zone demonstrated relatively constant and comparatively lower rates of proliferation throughout the cycle. Regional and cellular variations in nucleic acid synthesis in cyclic endometrium are likely to reflect differences in physiologic functions in target cells in response to cyclic hormonal stimuli.
在正常月经周期中，对体外掺入放射性胸腺嘧啶核苷后人体子宫内膜中标记细胞核的数量和分布进行了放射自显影分析。增殖率最高出现在功能层上三分之一的第8至10个周期日。与第19个周期日腺体内分泌活动同时出现的是，腺细胞增殖率降至接近零水平，并在此后保持不变。分泌中期小动脉盘绕和基质蜕膜前期变化与同位素掺入增加有关。经前期子宫内膜中的DNA合成仅限于表面上皮、前蜕膜和血管内皮。峡部、宫角区域以及基底层的子宫内膜在整个周期中显示出相对恒定且较低的增殖率。周期性子宫内膜中核酸合成的区域和细胞差异可能反映了靶细胞在周期性激素刺激下生理功能的差异。
