Strauss R G, Dase D, Doering P L
Am J Obstet Gynecol. 1979 Apr 15;133(8):891-3. doi: 10.1016/0002-9378(79)90307-7.
Forty parturient women received paracervical block (PCB) anesthetics during labor with 2-chloroprocaine (2-CP) and epinephrine in either normal saline or dextran. Thirty-six patients were though to have adequate anesthesia. Nineteen patients who recived 2-CP in saline had a mean duration of anesthesia lasting 55.4 min; one fetus developed post-PCB bradycardia. Seventeen patients who received 2-CP in dextran had a mean duration of anesthesia lasting 72.7 min; no fetal bradycardia was observed following PCB. Neonatal depression, expressed by 1 and 5 min Apgar scores below seven, was not observed in either group. The addition of dextran to 2-CP significantly prolongs the duration of PCB anesthesia and does not appear to compromise the fetus. The pain relief provided by a single PCB with 2-CP in dextran is still relatively short and would not persist throughout the active phase of labor in most parturient women.
40名产妇在分娩期间接受了宫颈旁阻滞（PCB）麻醉，使用2-氯普鲁卡因（2-CP）和肾上腺素，分别溶于生理盐水或右旋糖酐中。36名患者被认为麻醉效果良好。19名接受溶于生理盐水的2-CP的患者，平均麻醉持续时间为55.4分钟；1例胎儿在PCB后出现心动过缓。17名接受溶于右旋糖酐的2-CP的患者，平均麻醉持续时间为72.7分钟；PCB后未观察到胎儿心动过缓。两组均未观察到1分钟和5分钟阿氏评分低于7分所表示的新生儿抑制情况。在2-CP中添加右旋糖酐可显著延长PCB麻醉的持续时间，且似乎不会对胎儿造成损害。单次使用溶于右旋糖酐的2-CP进行PCB所提供的疼痛缓解时间仍然相对较短，在大多数产妇的产程活跃期不会持续。
