Spicer S S, Martin B J, Reynolds J P
Am J Pathol. 1972 Aug;68(2):423-40.
Sweat gland biopsies have been examined for their content of junctional-complex-associated (JCA) bodies. These bodies have been observed at the lumen of the gland as well as the intercellular canaliculi. A JCA body was encountered in each of two dark cells with uncondensed secretory granules; one of these cells was from a specimen in which no other bodies could be found after an extensive search. All other JCA bodies occurred in either clear or undifferentiated cells. Junctional-complex-associated bodies occupied pairs of adjacent cells rather frequently, but no cell revealed more than one body. The prevalence of JCA bodies varied widely among specimens. Glands lacking morphologic abnormalities, and others with some atypical features, disclosed few or no such bodies. Some glands that contained JCA bodies also contained coil cells with extensive vacuolization, which occurred as a manifestation of Hurler's disease or on an unexplained basis. Glands from a patient with cystic fibrosis exhibited the highest prevalence of JCA bodies. Some of the coil profiles in glands near a scar in one specimen were composed of undifferentiated cells with rare mitotic figures and no identifiable clear or dark cells. Numerous JCA bodies, particularly at the lumen, were found in sweat glands in this and another specimen containing frequent undifferentiated cells.
已对汗腺活检组织进行检查，以观察其连接复合体相关（JCA）小体的含量。这些小体在腺腔以及细胞间小管中均有观察到。在两个具有未浓缩分泌颗粒的暗细胞中均发现了一个JCA小体；其中一个细胞来自一个标本，在经过广泛搜索后未发现其他小体。所有其他JCA小体均出现在透明细胞或未分化细胞中。连接复合体相关小体相当频繁地占据相邻的细胞对，但没有细胞显示有超过一个小体。JCA小体的发生率在不同标本中差异很大。缺乏形态学异常的腺体以及其他具有一些非典型特征的腺体，很少或没有此类小体。一些含有JCA小体的腺体还含有具有广泛空泡化的螺旋细胞，这是Hurler病的一种表现形式，或者原因不明。一名囊性纤维化患者的腺体中JCA小体的发生率最高。在一个标本中靠近瘢痕处的腺体中的一些螺旋状结构由未分化细胞组成，有罕见的有丝分裂象，且没有可识别的透明细胞或暗细胞。在这个标本以及另一个含有频繁未分化细胞的标本的汗腺中，发现了大量JCA小体，尤其是在腺腔处。
