Davis F A
J Neurol Neurosurg Psychiatry. 1972 Aug;35(4):537-44. doi: 10.1136/jnnp.35.4.537.
Repetitive impulse conduction was studied in segmentally demyelinated peripheral nerves in guinea-pigs with experimental allergic neuritis (EAN) and in pressure-injured frog sciatic nerves. Normal guinea-pig sciatic-peroneal nerves maintained at 37°C conducted compound action potentials with only minor amplitude decreases at stimulus frequencies up to 200/sec. In contrast, nerves in EAN guinea-pigs maintained at 37°C demonstrated a rapidly progressive decrease in action potential amplitude when stimulated as slowly as 10-25/sec. The decrease is greater the higher the frequency of stimulation. At 100 stimuli/sec all EAN preparations showed more than a 50% reduction in action potential amplitude. These effects are reversible. In pressure-injured frog sciatic nerves similar effects occurred at stimulus frequencies as low as 50/sec. Normal frog nerves conducted up to 200 impulses/sec with little amplitude decrease. The probable mechanism and clinical significance of these results are discussed.
在患有实验性变应性神经炎（EAN）的豚鼠节段性脱髓鞘周围神经以及受压损伤的青蛙坐骨神经中研究了重复冲动传导。维持在37°C的正常豚鼠坐骨-腓总神经在刺激频率高达200/秒时传导复合动作电位，幅度仅有轻微下降。相比之下，维持在37°C的EAN豚鼠的神经在以低至10 - 25/秒的速度刺激时，动作电位幅度迅速逐渐下降。刺激频率越高，下降幅度越大。在100次刺激/秒时，所有EAN标本的动作电位幅度均降低超过50%。这些效应是可逆的。在受压损伤的青蛙坐骨神经中，在低至50/秒的刺激频率时也出现了类似效应。正常青蛙神经传导高达200次冲动/秒时，幅度几乎没有下降。讨论了这些结果的可能机制和临床意义。
