Low P A, McLeod J G
J Neurol Neurosurg Psychiatry. 1977 May;40(5):434-47. doi: 10.1136/jnnp.40.5.434.
The refractory period, the ability to transmit trains of impulses, and the effect of temperature on conduction, have been studied in the sciatic-tibial nerve trunks of Trembler mice, which suffer from a dominantly inherited hypertrophic neuropathy. Both the refractory period of transmission and the relative refractory period were increased in Trembler mice when compared with controls. The nerve trunks of Trembler mice were unable to conduct rapid trains of impulses, and conduction block occurred at rates of stimulation as low as 25 Hz. Cold block occurred at temperatures significantly higher in Trembler nerves than in controls. The conduction velocity increased in an approximately linear fashion in both Trembler and control nerves when the temperature was raised from 20 degrees C to 40 degrees C, and the slopes were not significantly different. The Q10 (27 degrees C-37 degrees C) was 1.5 and 1.6 for control and Trembler nerves respectively. Conduction block was regularly observed in Trembler nerves when the temperature was raised within the physiological range. The abnormalities are related to the pathological changes of chronic demyelination.
在患有显性遗传性肥大性神经病的颤抖小鼠的坐骨 - 胫神经干中，研究了不应期、传递冲动序列的能力以及温度对传导的影响。与对照组相比，颤抖小鼠的传递不应期和相对不应期均延长。颤抖小鼠的神经干无法传导快速的冲动序列，并且在低至25Hz的刺激频率下就会出现传导阻滞。颤抖神经出现冷阻滞的温度明显高于对照组。当温度从20℃升高到40℃时，颤抖神经和对照神经的传导速度均以近似线性的方式增加，且斜率无显著差异。对照神经和颤抖神经在27℃ - 37℃的Q10分别为1.5和1.6。当在生理范围内升高温度时，在颤抖神经中经常观察到传导阻滞。这些异常与慢性脱髓鞘的病理变化有关。
