Kerns J M, Smith D R, Jannotta F S, Alper M G
Am J Ophthalmol. 1979 Feb;87(2):225-33. doi: 10.1016/0002-9394(79)90148-x.
A 57-year-old woman had symptoms of oculomotor nerve palsy first appearing one year before successful surgical ligation of a saccular aneurysm arising from the right posterior cerebral artery. During the subsequent postoperative period of two years, oculomotor nerve functions improved as the result of regeneration. Extensive morphometric evaluation of the regenerated nerve was compared to the normal side at the light microscopic level. The affected nerve showed a reduction in the transverse area (62%), estimated number of fibers (49%), and mean diameter of myelinated axons (23%). The normal g-ratio of axon to total diameter was almost constant at 0.64, but on the regenerated side it increased to 0.73. An increase in unmyelinated axons and connective tissue endoneurium was evident at the ultrastructural level. The significance of these marked quantitative changes was compared to the partial return of oculomotor nerve function.
一名57岁女性在成功手术结扎源自右大脑后动脉的囊状动脉瘤前一年首次出现动眼神经麻痹症状。在随后的两年术后期间，动眼神经功能因再生而改善。在光学显微镜水平对再生神经进行了广泛的形态计量学评估，并与正常侧进行了比较。患侧神经的横截面积减少了62%，估计纤维数量减少了49%，有髓轴突的平均直径减少了23%。轴突与总直径的正常g比值几乎恒定在0.64，但在再生侧增加到了0.73。在超微结构水平上，无髓轴突和结缔组织神经内膜明显增加。将这些显著的定量变化的意义与动眼神经功能的部分恢复进行了比较。
