Preston N W, Stanbridge T N
Br Med J. 1972 Aug 19;3(5824):448-51. doi: 10.1136/bmj.3.5824.448.
A study of pertussis infections in 186 children under 11 years of age in the Manchester region during 1969-71 suggests that recently-manufactured vaccines have been more effective than those made before 1967. The earlier vaccines were effective mainly against the serotypes of Bordetella pertussis possessing antigen 2, while those made from 1967 are more nearly equal in their effectiveness against thedi fferent serotypes. A booster dose of the earlier vaccines did not prevent infection with type 1,3 organisms, but we obtained a positive culture from only one child who had received four doses of recent vaccine.Simultaneous infection of a child with two or more serotypes was frequently seen. The predominant serotype in a patient was usually type 1,3; less often it was type 1,2,3 or type 1,2; it was never type 1. A change of serotype sometimes occurs during the course of the illness and is probably directed by the vaccination status of the patient in relation to the serotype of the initial infection.Our findings emphasize the need for vaccines to contain adequate amounts of all three pertussis agglutinogens, and for satisfactory immunization schedules to be used in their administration.
1969年至1971年期间，对曼彻斯特地区186名11岁以下儿童的百日咳感染情况进行的一项研究表明，近期生产的疫苗比1967年以前生产的疫苗更有效。早期疫苗主要对具有抗原2的百日咳博德特氏菌血清型有效，而1967年以后生产的疫苗对不同血清型的有效性更为相近。早期疫苗的加强剂量不能预防1、3型菌株感染，但在仅一名接种了四剂近期疫苗的儿童身上获得了阳性培养结果。儿童同时感染两种或更多血清型的情况很常见。患者中占主导地位的血清型通常是1、3型；较少见的是1、2、3型或1、2型；从未出现过1型。在病程中有时会发生血清型的变化，这可能与患者相对于初始感染血清型的疫苗接种状况有关。我们的研究结果强调，疫苗需要含有足够量的所有三种百日咳凝集原，并且在接种时要采用令人满意的免疫接种方案。
