Toma S, Lo H, Magus M
Can Med Assoc J. 1978 Oct 7;119(7):722-4.
A study was done to determine the major antigenic factors of Bordetella pertussis strains isolated throughout Canada and whether these isolates have the same antigenic structure as the bacilli in the currently used vaccines. Testing for the major pertussis antigens, factors 1, 2 and 3, was conducted with 440 freshly isolated strains of B. pertussis received from seven canadian provinces between August 1976 and February 1978 and six batches of pertussis vaccine or immunizing agents containing pertussis vaccine. With the aid of specific antisera prepared in rabbits, the antigenic factors were detected by a slide agglutination technique. Almost all (98.9%) of the pertussis strains examined were serotype 1,3. All six batches of pertussis vaccine or immunizing agents containing pertussis vaccine proved to be rich in each of the three main pertussis agglutinogens.
开展了一项研究，以确定加拿大各地分离出的百日咳博德特氏菌菌株的主要抗原因素，以及这些分离菌株是否具有与当前使用疫苗中的杆菌相同的抗原结构。对1976年8月至1978年2月期间从加拿大七个省份收到的440株新鲜分离的百日咳博德特氏菌菌株以及六批百日咳疫苗或含百日咳疫苗的免疫制剂进行了主要百日咳抗原（因素1、2和3）检测。借助于用兔子制备的特异性抗血清，通过玻片凝集技术检测抗原因素。几乎所有（98.9%）检测的百日咳菌株均为1,3血清型。所有六批百日咳疫苗或含百日咳疫苗的免疫制剂均被证明富含三种主要百日咳凝集原中的每一种。
