Kroll K, Hendriks F F, Schipperheyn J J
Am J Physiol. 1979 Apr;236(4):H652-6. doi: 10.1152/ajpheart.1979.236.4.H652.
An adjustable constant-flow coronary artery perfusion system has been developed for use in the anesthetized closed-chest dog. Coronary flow and perfusion pressure measurements are obtained over the entire autoregulatory range. Coronary flow was briefly diverted to a bypass cannula and then returned to its original level. Coronary vasodilatation resulted in a fall of perfusion pressure below its preocclusion value, but recovery of vascular tone was complete in about twice the time required during unrestricted reactive hyperemia. It is concluded that no flow debt repayment is required for the restoration of vascular tone after brief occlusions. In the measurements made with this system, intramyocardial pressure distribution is not influenced by thoracotomy, pericardotomy, or positive-pressure respiration, and surgical trauma is minimal.
已开发出一种可调节的恒流冠状动脉灌注系统，用于麻醉的闭胸犬。在整个自动调节范围内获取冠状动脉流量和灌注压力测量值。冠状动脉血流短暂分流至旁路插管，然后恢复到原来水平。冠状动脉血管舒张导致灌注压力降至其闭塞前值以下，但血管张力恢复所需时间约为无限制反应性充血期间所需时间的两倍。得出的结论是，短暂闭塞后恢复血管张力不需要偿还血流亏欠。在使用该系统进行的测量中，心肌内压力分布不受开胸、心包切开术或正压呼吸的影响，手术创伤最小。
