胆碱能药物和腺苷酸环化酶激活剂对致敏淋巴细胞细胞毒性作用的改变。
Alteration of the cytotoxic action of sensitized lymphocytes by cholinergic agents and activators of adenylate cyclase.
作者信息
Strom T B, Deisseroth A, Morganroth J, Carpenter C B, Merrill J P
出版信息
Proc Natl Acad Sci U S A. 1972 Oct;69(10):2995-9. doi: 10.1073/pnas.69.10.2995.
Abstract
The cytotoxic action of lymphocytes upon cells bearing alloantigens to which they are sensitized is inhibited by agents that elevate intracellular amounts of 3':5'-cyclic AMP: prostaglandin E(1), cholera toxin, and theophylline. Cholinergic agents, added in the range of 1 to 100 pM, enhance cytotoxicity, an effect that is blocked by atropine. Because cholinergic agents elevate cyclic GMP in other in vitro systems, these findings suggest that the cytotoxic process effected by sensitized lymphocytes is a secretory phenomenon modulated by cyclic AMP and cyclic GMP.
摘要
能提高细胞内3':5'-环磷酸腺苷（3':5'-cyclic AMP）含量的物质，如前列腺素E(1)、霍乱毒素和茶碱，可抑制淋巴细胞对带有其致敏的同种异体抗原的细胞的细胞毒性作用。添加浓度在1至100皮摩尔范围内的胆碱能药物可增强细胞毒性，而阿托品可阻断这一效应。由于胆碱能药物在其他体外系统中可提高环磷酸鸟苷（cyclic GMP）水平，这些发现表明，致敏淋巴细胞所产生的细胞毒性过程是一种受环磷酸腺苷和环磷酸鸟苷调节的分泌现象。
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