Witter R L, Solomon J J
Infect Immun. 1971 Oct;4(4):356-61. doi: 10.1128/iai.4.4.356-361.1971.
Parameters of turkey herpesvirus (HVT) infection were followed sequentially from hatching through 20 weeks in two commercial turkey flocks. Maternal antibody was uniformly present at hatching but decreased below detectable levels by the 3rd week. Virus was first isolated at the 5th and 6th weeks and thereafter spread rapidly within the flocks. Development of active antibody followed that of viremia by 1 week. Both virus and antibody were present in virtually all turkeys after the 7th or 10th week; however, the incidence of tumors was negligible. Dust and litter from infected flocks were negative for HVT by poult bioassay, but the infection was easily transmitted by exposure of poults to dirty isolation cages or air from HVT-infected turkeys. Attempts to demonstrate congenital transmission of HVT by direct virus isolation from embryos of infected breeders or by isolation rearing procedures were unsuccessful.
在两个商业火鸡群中，从孵化到20周龄依次追踪火鸡疱疹病毒（HVT）感染的参数。母源抗体在孵化时均一存在，但到第3周时降至检测不到的水平以下。病毒在第5周和第6周首次分离出来，此后在鸡群中迅速传播。活性抗体的产生比病毒血症晚1周。第7周或第10周后，几乎所有火鸡体内都存在病毒和抗体；然而，肿瘤的发生率可忽略不计。通过雏禽生物测定法，感染鸡群的灰尘和垫料中HVT呈阴性，但将雏禽暴露于脏的隔离笼或感染HVT的火鸡的空气中，感染很容易传播。通过从感染种鸡的胚胎中直接分离病毒或通过隔离饲养程序来证明HVT的先天性传播的尝试均未成功。
