大鼠离体结肠作为血管紧张素的特异性检测器官。
The rat isolated colon as a specific assay organ for angiotensin.
作者信息
Gagnon D J, Sirois P
出版信息
Br J Pharmacol. 1972 Sep;46(1):89-93. doi: 10.1111/j.1476-5381.1972.tb06851.x.
Abstract
- The antagonism of the contractile effects of prostaglandins F(2alpha) and E(2) by polyphloretin phosphate (PPP) was studied on the rat isolated colon.2. PPP (20 mug/ml) was found to reduce the myotropic action of angiotensin I (10 ng/ml) and II (0.3 ng/ml) whereas larger doses of both agents were not influenced.3. It is concluded that when a mixture of antagonists is used, including PPP, the rat isolated colon can be used to assay angiotensin with accuracy and specificity. The addition of 8-L-ala-AT(II) affords a further test of specificity.
摘要
在大鼠离体结肠上研究了聚磷酸根皮苷（PPP）对前列腺素F（2α）和E（2）收缩作用的拮抗作用。
发现PPP（20微克/毫升）可降低血管紧张素I（10纳克/毫升）和II（0.3纳克/毫升）的促肌作用，而更高剂量的这两种药物则不受影响。
得出结论，当使用包括PPP在内的拮抗剂混合物时，大鼠离体结肠可用于准确且特异的血管紧张素测定。添加8-L-丙氨酸-血管紧张素II（AT（II））可进一步进行特异性测试。
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