甲基强的松龙对卡介苗介导的兔肺泡巨噬细胞某些变化的影响。
Effect of methylprednisolone on some BCG-mediated changes in rabbit alveolar macrophage.
作者信息
Wang P, Franson R C, DeChatelet L R, Waite M, McCall C E
出版信息
Infect Immun. 1972 Dec;6(6):982-7. doi: 10.1128/iai.6.6.982-987.1972.
The effect of methylprednisolone sodium succinate treatment on Bacillus Calmette-Guérin (BCG) immunization was examined in alveolar macrophages of New Zealand White rabbits. Intravenous BCG injection caused a marked increase in cell number and in the hexosemonophosphate shunt activity. There was also a selective augmentation in the activity of acid phosphatase and beta-glucuronidase and an increase in lysosomal density. Activity of the lysosomal phospholipases was decreased. Steroid treatment suppressed the BCG-induced increase in cell number, hexosemonophosphate shunt activity, acid phosphatase, and beta-glucuronidase, and prevented the increase in lysosomal density. On the other hand, steroid treatment increased the activity of the phospholipases to levels higher than either control values or those obtained with cells from BCG-treated rabbits.
在新西兰白兔的肺泡巨噬细胞中研究了琥珀酸钠甲泼尼龙治疗对卡介苗（BCG）免疫的影响。静脉注射卡介苗导致细胞数量和磷酸己糖旁路活性显著增加。酸性磷酸酶和β-葡萄糖醛酸酶的活性也有选择性增强，溶酶体密度增加。溶酶体磷脂酶的活性降低。类固醇治疗抑制了卡介苗诱导的细胞数量增加、磷酸己糖旁路活性、酸性磷酸酶和β-葡萄糖醛酸酶，并阻止了溶酶体密度的增加。另一方面，类固醇治疗使磷脂酶的活性增加到高于对照值或卡介苗处理兔细胞所获得的值的水平。
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