肾上腺皮质类固醇生成：前列腺素的作用。
Adrenocortical steroidogenesis: the effects of prostaglandins.
作者信息
Saruta T, Kaplan N M
出版信息
J Clin Invest. 1972 Sep;51(9):2246-51. doi: 10.1172/JCI107033.
Abstract
Prostaglandins E(1) and E(2) significantly stimulated the synthesis of aldosterone, corticosterone, and to a lesser degree, cortisol in the outer slices of beef adrenal tissue. PGA, PGF(1a), and PGF(2a) were ineffective.PGE(1) was found to stimulate steroidogenesis in a manner similar to that of adrenocorticotropin (ACTH) in (a) needing calcium, (b) being inhibited by puromycin but not actinomycin D, (c) increasing the levels of cyclic AMP, and (d) not having an additive effect to exogenous cyclic AMP. PGE(1) did not produce an additive effect with either submaximal or maximal amounts of ACTH but did have an additive effect with angiotensin. These results are in keeping with the hypothesis that PGE(1) shares a receptor site on the plasma membrane with ACTH.
摘要
前列腺素E(1)和E(2)能显著刺激牛肉肾上腺组织外层切片中醛固酮、皮质酮的合成，对皮质醇的合成刺激作用较小。前列腺素A、PGF(1a)和PGF(2a)则无此作用。研究发现，PGE(1)刺激类固醇生成的方式与促肾上腺皮质激素（ACTH）类似，具体表现为：(a) 需要钙；(b) 受嘌呤霉素抑制，但不受放线菌素D抑制；(c) 增加环磷酸腺苷（cAMP）水平；(d) 对外源性cAMP无叠加效应。PGE(1)与亚最大量或最大量的ACTH均无叠加效应，但与血管紧张素具有叠加效应。这些结果符合以下假设：PGE(1)与ACTH在质膜上共用一个受体位点。
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