• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The mechanism of enzyme-catalyzed reduced nicotinamide adenine dinucleotide-dependent reductions. Substituent and isotope effects in the yeast alcohol dehydrogenase reaction.

作者信息

Klinman J P

出版信息

J Biol Chem. 1972 Dec 25;247(24):7977-87.

PMID:4344986
Abstract
摘要

相似文献

1
The mechanism of enzyme-catalyzed reduced nicotinamide adenine dinucleotide-dependent reductions. Substituent and isotope effects in the yeast alcohol dehydrogenase reaction.
J Biol Chem. 1972 Dec 25;247(24):7977-87.
2
The use of synthetic inhibitors to study the interaction of nicotinamide adenine dinucleotide with yeast alcohol dehydrogenase.使用合成抑制剂研究烟酰胺腺嘌呤二核苷酸与酵母乙醇脱氢酶的相互作用。
Mol Biol. 1974 May;7(6):723-8.
3
Variation of transition-state structure as a function of the nucleotide in reactions catalyzed by dehydrogenases. 1. Liver alcohol dehydrogenase with benzyl alcohol and yeast aldehyde dehydrogenase with benzaldehyde.脱氢酶催化反应中过渡态结构随核苷酸的变化。1. 肝醇脱氢酶催化苯甲醇反应以及酵母醛脱氢酶催化苯甲醛反应。
Biochemistry. 1984 Nov 6;23(23):5471-8. doi: 10.1021/bi00318a015.
4
Magnetic resonance studies of the geometry of bound nicotinamide adenine dinucleotide and isobutyramide on spin-labeled alcohol dehydrogenase.自旋标记乙醇脱氢酶上结合的烟酰胺腺嘌呤二核苷酸和异丁酰胺几何结构的磁共振研究。
Biochemistry. 1974 Apr 9;13(8):1711-8. doi: 10.1021/bi00705a024.
5
Isotope effects and structure-reactivity correlations in the yeast alcohol dehydrogenase reaction. A study of the enzyme-catalyzed oxidation of aromatic alcohols.酵母乙醇脱氢酶反应中的同位素效应与结构-反应性关联。芳香醇酶催化氧化的研究。
Biochemistry. 1976 May 4;15(9):2018-26. doi: 10.1021/bi00654a032.
6
Effects of pressure on deuterium isotope effects of yeast alcohol dehydrogenase using alternative substrates.压力对使用替代底物的酵母乙醇脱氢酶氘同位素效应的影响。
Arch Biochem Biophys. 2005 Jan 1;433(1):335-40. doi: 10.1016/j.abb.2004.09.033.
7
Electronic substituent effects during the liver alcohol dehydrogenase catalyzed reduction of aromatic aldehydes.
Biochemistry. 1974 Jan 1;13(1):60-4. doi: 10.1021/bi00698a010.
8
Acid-base catalysis in the yeast alcohol dehydrogenase reaction.酵母乙醇脱氢酶反应中的酸碱催化作用。
J Biol Chem. 1975 Apr 10;250(7):2569-73.
9
Roles of zinc ion and reduced coenzyme in the formation of a transient chemical intermediate during the equine liver alcohol dehydrogenase catalyzed reduction of an aromatic aldehyde.锌离子和还原型辅酶在马肝乙醇脱氢酶催化芳香醛还原过程中形成瞬态化学中间体的作用。
Biochemistry. 1973 Nov 20;12(24):4882-92. doi: 10.1021/bi00748a012.
10
Variation of transition-state structure as a function of the nucleotide in reactions catalyzed by dehydrogenases. 2. Formate dehydrogenase.脱氢酶催化反应中过渡态结构随核苷酸的变化。2. 甲酸脱氢酶。
Biochemistry. 1984 Nov 6;23(23):5479-88. doi: 10.1021/bi00318a016.

引用本文的文献

1
A Hammett Study of Clostridium acetobutylicum Alcohol Dehydrogenase (CaADH): An Enzyme with Remarkable Substrate Promiscuity and Utility for Organic Synthesis.丙酮丁醇梭菌乙醇脱氢酶（CaADH）的哈米特研究：一种具有显著底物选择性和有机合成用途的酶
Synlett. 2020 Feb;31(3):237-247. doi: 10.1055/s-0039-1691576. Epub 2020 Jan 16.
2
A Foundational Shift in Models for Enzyme Function.酶功能模型的根本性转变。
J Am Chem Soc. 2025 May 7;147(18):14884-14904. doi: 10.1021/jacs.5c02388. Epub 2025 Apr 25.
3
Kinetic isotope effect reveals rate-limiting step in green-to-red photoconvertible fluorescent proteins.
动力学同位素效应揭示了绿色到红色光致变色荧光蛋白中的限速步骤。
Protein Sci. 2024 Jul;33(7):e5069. doi: 10.1002/pro.5069.
4
Solvent isotope and mutagenesis studies on the proton relay system in yeast alcohol dehydrogenase 1.酵母醇脱氢酶 1 中质子传递系统的溶剂同位素和诱变研究。
Chem Biol Interact. 2024 Jan 25;388:110853. doi: 10.1016/j.cbi.2023.110853. Epub 2023 Dec 25.
5
The Pseudomonas aeruginosa PAO1 metallo flavoprotein d-2-hydroxyglutarate dehydrogenase requires Zn for substrate orientation and activation.铜绿假单胞菌 PAO1 的金属黄素蛋白 d-2-羟戊二酸脱氢酶需要锌来进行底物定向和激活。
J Biol Chem. 2023 Mar;299(3):103008. doi: 10.1016/j.jbc.2023.103008. Epub 2023 Feb 11.
6
Role of geochemical protoenzymes (geozymes) in primordial metabolism: specific abiotic hydride transfer by metals to the biological redox cofactor NAD.地球化学原酶（geozymes）在原始代谢中的作用：金属向生物氧化还原辅因子 NAD 进行特定的非生物氢化物转移。
FEBS J. 2022 Jun;289(11):3148-3162. doi: 10.1111/febs.16329. Epub 2022 Jan 3.
7
Inverse Solvent Isotope Effects in Enzyme-Catalyzed Reactions.酶催化反应中的反溶剂同位素效应。
Molecules. 2020 Apr 21;25(8):1933. doi: 10.3390/molecules25081933.
8
Moving Through Barriers in Science and Life.穿越科学与生活的藩篱。
Annu Rev Biochem. 2019 Jun 20;88:1-24. doi: 10.1146/annurev-biochem-013118-111217.
9
Primary Deuterium Kinetic Isotope Effects: A Probe for the Origin of the Rate Acceleration for Hydride Transfer Catalyzed by Glycerol-3-Phosphate Dehydrogenase.初级氘动力学同位素效应：甘油-3-磷酸脱氢酶催化氢化物转移速率加速起源的探针
Biochemistry. 2018 Jul 24;57(29):4338-4348. doi: 10.1021/acs.biochem.8b00536. Epub 2018 Jul 10.
10
Contribution of buried distal amino acid residues in horse liver alcohol dehydrogenase to structure and catalysis.马肝醇脱氢酶中埋藏的远端氨基酸残基对结构和催化的贡献。
Protein Sci. 2018 Mar;27(3):750-768. doi: 10.1002/pro.3370. Epub 2018 Jan 25.