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1
Evaluation of the rate-limiting steps in the pathway of glucose metabolism in kidney cortex of normal, diabetic, cortisone-treated and growth hormone-treated rats.对正常、糖尿病、可的松处理及生长激素处理大鼠肾皮质中葡萄糖代谢途径限速步骤的评估。
Biochem J. 1972 Aug;128(5):1293-301. doi: 10.1042/bj1281293.
2
Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate.在分离的灌注大鼠肝脏中，葡萄糖、果糖和乳酸对糖酵解及糖异生关键酶的诱导和抑制作用。
Biochem J. 1973 May;134(1):143-56. doi: 10.1042/bj1340143.
3
The effects of pregnancy and lactation on the activities in rat liver of some enzymes associated with glucose metabolism.妊娠和哺乳期对大鼠肝脏中一些与葡萄糖代谢相关酶活性的影响。
Biochim Biophys Acta. 1975 Nov 10;411(1):22-9. doi: 10.1016/0304-4165(75)90281-0.
4
Factors involved in changes in hepatic lipogenesis during development of the rat.大鼠发育过程中肝脏脂肪生成变化所涉及的因素。
Biochem J. 1970 Jun;118(1):155-62. doi: 10.1042/bj1180155.
5
[Activity of gluconeogenetic enzymes of rat kidney cortex during acute hypoxia].[急性缺氧时大鼠肾皮质糖异生酶的活性]
Biull Eksp Biol Med. 1978 Apr;85(4):415-6.
6
A comparison of the effects of diabetes induced with either alloxan or streptozotocin and of starvation on the activities in rat liver of the key enzymes of gluconeogenesis.用四氧嘧啶或链脲佐菌素诱导糖尿病以及饥饿对大鼠肝脏糖异生关键酶活性影响的比较。
Biochem J. 1970 Nov;120(1):95-103. doi: 10.1042/bj1200095.
7
[The isoenzyme pattern of the rat uterus. I. Comparative studies in the intact uterus].[大鼠子宫的同工酶模式。I. 完整子宫的比较研究]
Z Geburtshilfe Gynakol. 1970;173(3):330-8.
8
Gluconeogenesis in the cow. The effects of a glucocorticoid on hepatic intermediary metabolism.奶牛的糖异生作用。一种糖皮质激素对肝脏中间代谢的影响。
Biochem J. 1970 Mar;116(5):865-74. doi: 10.1042/bj1160865.
9
Glucose synthesis from labelled precursors in kidney cortical slices of normal, diabetic, cortisone-treated and growth hormone-treated rats.正常、糖尿病、用可的松治疗以及用生长激素治疗的大鼠肾皮质切片中由标记前体合成葡萄糖的情况。
Indian J Biochem. 1970 Mar;7(1):45-9.
10
Enzymes of the pyruvate cycle in a case of glycogenosis.糖原贮积症一例中的丙酮酸循环酶
Ital J Biochem. 1968 Mar-Apr;17(2):107-17.

引用本文的文献

1
Tubular Cell Glucose Metabolism Shift During Acute and Chronic Injuries.急性和慢性损伤期间肾小管细胞葡萄糖代谢的转变
Front Med (Lausanne). 2021 Oct 29;8:742072. doi: 10.3389/fmed.2021.742072. eCollection 2021.
2
The vital role of ATP citrate lyase in chronic diseases.三磷酸柠檬酸裂解酶在慢性疾病中的重要作用。
J Mol Med (Berl). 2020 Jan;98(1):71-95. doi: 10.1007/s00109-019-01863-0. Epub 2019 Dec 19.
3
Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes.使用 MitoQ 进行靶向线粒体治疗可达到与血管紧张素转换酶抑制相当的肾脏保护作用，但在糖尿病中没有联合协同作用。
Sci Rep. 2017 Nov 9;7(1):15190. doi: 10.1038/s41598-017-15589-x.
4
Angiotensin-converting enzyme inhibition curbs tyrosine nitration of mitochondrial proteins in the renal cortex during the early stage of diabetes mellitus in rats.血管紧张素转化酶抑制作用可抑制糖尿病大鼠早期肾皮质中线粒体蛋白酪氨酸硝化。
Clin Sci (Lond). 2013 Apr;124(8):543-52. doi: 10.1042/CS20120251.
5
Effect of 5-thio-D-glucose on blood glucose and glucose-6-phosphatase activity in mice.5-硫代-D-葡萄糖对小鼠血糖及葡萄糖-6-磷酸酶活性的影响。
Experientia. 1982 Aug 15;38(8):910-2. doi: 10.1007/BF01953648.

本文引用的文献

1
The oxygen consumption and carbohydrate metabolism of the retractor muscle of the foot of Mytilus edulis.紫贻贝足部牵缩肌的耗氧量与碳水化合物代谢
J Physiol. 1936 Jun 10;87(1):56-66. doi: 10.1113/jphysiol.1936.sp003388.
2
Development of gluconeogenesis in neonatal rat liver. Effect of triamcinolone.新生大鼠肝糖异生的发育。曲安奈德的影响。
Biochem J. 1967 Dec;105(3):1219-27. doi: 10.1042/bj1051219.
3
Studies involving enzymic phosphorylation. I. The hexokinase activity of rat tissues.涉及酶促磷酸化的研究。I. 大鼠组织的己糖激酶活性。
Biochem J. 1952 Jan;50(3):407-15. doi: 10.1042/bj0500407.
4
Enzymatic synthesis of citric acid. II. Crystalline condensing enzyme.柠檬酸的酶促合成。II. 结晶缩合酶。
J Biol Chem. 1951 Dec;193(2):691-702.
5
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
6
Stimulation of amino acid transport in isolated diaphragm by growth hormone added in vitro.体外添加生长激素对分离膈膜中氨基酸转运的刺激作用。
Science. 1959 Dec 11;130(3389):1653-4. doi: 10.1126/science.130.3389.1653.
7
SOME PROPERTIES OF FRUCTOSE 1,6-DIPHOSPHATASE OF RAT LIVER AND THEIR RELATION TO THE CONTROL OF GLUCONEOGENESIS.大鼠肝脏果糖1,6 -二磷酸酶的某些特性及其与糖异生调控的关系。
Biochem J. 1965 Jun;95(3):767-74. doi: 10.1042/bj0950767.
8
PYRUVATE CARBOXYLASE. I. NATURE OF THE REACTION.丙酮酸羧化酶。一、反应性质
J Biol Chem. 1963 Aug;238:2603-8.
9
Renal gluconeogenesis. The effect of diet on the gluconeogenic capacity of rat-kidney-cortex slices.肾糖异生。饮食对大鼠肾皮质切片糖异生能力的影响。
Biochem J. 1963 Jan;86(1):22-7. doi: 10.1042/bj0860022.
10
Increase in liver acetyl-coenzyme A during ketosis.酮症期间肝脏乙酰辅酶A增加。
Biochem Biophys Res Commun. 1963 Feb 18;10:333-9. doi: 10.1016/0006-291x(63)90534-5.

对正常、糖尿病、可的松处理及生长激素处理大鼠肾皮质中葡萄糖代谢途径限速步骤的评估。

Evaluation of the rate-limiting steps in the pathway of glucose metabolism in kidney cortex of normal, diabetic, cortisone-treated and growth hormone-treated rats.

作者信息

Joseph P K, Subrahmanyam K

出版信息

Biochem J. 1972 Aug;128(5):1293-301. doi: 10.1042/bj1281293.

DOI:10.1042/bj1281293
PMID:4345356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1174017/
Abstract
  1. The activities of gluconeogenic and glycolytic enzymes and the concentrations of citrate, ammonia, amino acids, glycogen, glucose 6-phosphate, acetyl-CoA, lactate and pyruvate were measured in kidney cortex of normal, diabetic, cortisone-treated and growth hormone-treated rats. 2. In kidney cortex of diabetic, cortisone-treated and growth hormone-treated rats the activities of glucose 6-phosphatase (EC 3.1.3.9), fructose 1,6-diphosphatase (EC 3.1.3.11) and phosphopyruvate carboxylase (EC 4.1.1.32) were increased. 3. The activities of glutamate dehydrogenase (EC 1.4.1.3), alanine aminotransferase (EC 2.6.1.2), aspartate aminotransferase (EC 2.6.1.10) and pyruvate carboxylase (EC 6.4.1.1) were increased in diabetic and cortisone-treated rats. In growth hormone-treated rats the activity of aspartate aminotransferase was depressed but those of the other three enzymes were unchanged. 4. The activity of hexokinase (EC 2.7.1.1) was not altered in any of these conditions. Phosphofructokinase (EC 2.7.1.11) activity was depressed only in growth hormone-treated rats. Pyruvate kinase (EC 2.7.1.40) activity was depressed in cortisone-treated and growth hormone-treated rats but unchanged in diabetic rats. 5. Amino acids, acetyl-CoA and glucose 6-phosphate contents were increased in rat kidneys in all these three conditions. Ammonia content was increased in diabetic and cortisone-treated rats but was markedly diminished in growth hormone-treated rats. 6. The [lactate]/[pyruvate] ratio was elevated in diabetic and cortisone-treated rats but unchanged in growth hormone-treated rats. Citrate content was increased in the kidney cortex of diabetic and growth hormone-treated rats but was unchanged in cortisone-treated rats. The activity of ATP citrate lyase (EC 4.1.3.8) was depressed in diabetic and growth hormone-treated rats but was increased in cortisone-treated rats. 7. Glycogen content was moderately elevated in growth hormone-treated rats and markedly elevated in diabetic rats, whereas no change in glycogen content was observed in cortisone-treated rats. Glycogen synthetase (EC 2.4.1.11) activity was unchanged in all these three conditions. Phosphorylase (EC 2.4.1.1) activity was not affected in cortisone-treated rats but was depressed in diabetic and growth hormone-treated rats.
摘要
  1. 测定了正常、糖尿病、可的松处理及生长激素处理大鼠肾皮质中糖异生和糖酵解酶的活性，以及柠檬酸、氨、氨基酸、糖原、6-磷酸葡萄糖、乙酰辅酶A、乳酸和丙酮酸的浓度。2. 在糖尿病、可的松处理及生长激素处理大鼠的肾皮质中，6-磷酸葡萄糖磷酸酶（EC 3.1.3.9）、果糖1,6-二磷酸酶（EC 3.1.3.11）和磷酸丙酮酸羧化酶（EC 4.1.1.32）的活性增加。3. 糖尿病和可的松处理大鼠中谷氨酸脱氢酶（EC 1.4.1.3）、丙氨酸转氨酶（EC 2.6.1.2）、天冬氨酸转氨酶（EC 2.6.1.10）和丙酮酸羧化酶（EC 6.4.1.1）的活性增加。在生长激素处理大鼠中，天冬氨酸转氨酶活性降低，但其他三种酶的活性未改变。4. 在任何这些情况下，己糖激酶（EC 2.7.1.1）的活性均未改变。磷酸果糖激酶（EC 2.7.1.11）的活性仅在生长激素处理的大鼠中降低。丙酮酸激酶（EC 2.7.1.40）的活性在可的松处理和生长激素处理的大鼠中降低，但在糖尿病大鼠中未改变。5. 在所有这三种情况下，大鼠肾脏中的氨基酸、乙酰辅酶A和6-磷酸葡萄糖含量均增加。糖尿病和可的松处理大鼠中的氨含量增加，但生长激素处理大鼠中的氨含量明显减少。6. 糖尿病和可的松处理大鼠中[乳酸]/[丙酮酸]比值升高，但生长激素处理大鼠中该比值未改变。糖尿病和生长激素处理大鼠肾皮质中的柠檬酸含量增加，但可的松处理大鼠中柠檬酸含量未改变。糖尿病和生长激素处理大鼠中ATP柠檬酸裂解酶（EC 4.1.3.8）的活性降低，但可的松处理大鼠中该酶活性增加。7. 生长激素处理大鼠中的糖原含量适度升高，糖尿病大鼠中的糖原含量显著升高，而可的松处理大鼠中的糖原含量未观察到变化。在所有这三种情况下，糖原合成酶（EC 2.4.1.11）的活性均未改变。磷酸化酶（EC 2.4.1.1）的活性在可的松处理大鼠中未受影响，但在糖尿病和生长激素处理大鼠中降低。