Hamet P, Kuchel O, Fraysse J, Genest J
Can Med Assoc J. 1974 Aug 17;111(4):323-8.
In a previous study we observed an increase in urinary cyclic AMP in labile hypertension in the upright position and during isoproterenol infusion, in contrast to a decrease in control subjects. In the present study we measured the plasma level of cyclic AMP in control subjects and patients with various types of hypertension. We obtained the following results: (1) plasma cyclic AMP increases in response to upright posture in control subjects and hypertensive patients; (2) values of cyclic AMP in the recumbent and upright positions are comparable in control subjects and patients with essential hypertension, but are significantly higher in those with true renovascular hypertension due to bilateral renal artery stenosis; (3) propranolol inhibits the increase of plasma cyclic AMP in response to posture in control subjects, but has an opposite effect in labile hypertension where there is a further increase; (4) the rise in blood pressure in pheochromocytoma is associated with a considerable increase in plasma cyclic AMP.Present and previous data suggest that kidney handling of cyclic AMP is abnormal in hypertension, and that the specific defect may be related to the type of hypertension.
在先前的一项研究中，我们观察到，与对照组受试者降低相反，不稳定型高血压患者在直立位及输注异丙肾上腺素期间尿中环磷酸腺苷（cAMP）增加。在本研究中，我们测定了对照组受试者及各类高血压患者血浆cAMP水平。我们得到了以下结果：（1）对照组受试者和高血压患者血浆cAMP水平在直立位时均升高；（2）对照组受试者和原发性高血压患者卧位和直立位时的cAMP值相当，但双侧肾动脉狭窄所致真性肾血管性高血压患者的cAMP值显著更高；（3）普萘洛尔可抑制对照组受试者因体位改变引起的血浆cAMP升高，但在不稳定型高血压患者中却有相反作用，即导致cAMP进一步升高；（4）嗜铬细胞瘤患者血压升高与血浆cAMP显著增加有关。目前和先前的数据表明，高血压患者肾脏对cAMP的处理存在异常，且具体缺陷可能与高血压类型有关。
