Grünspan M, Antweiler H, Dehnen W
Br J Ind Med. 1973 Jan;30(1):74-7. doi: 10.1136/oem.30.1.74.
74-77. The total amount of phospholipids and the contents of sphingomyelin, phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine have been estimated in the lungs of rats from 2 to 90 days after intra-tracheal injections of quartz and corundum, respectively. A significant increase in the contents of lung total phospholipids and of all phospholipid fractions examined was caused by quartz. The first increase was noted 48 hours after quartz application; after 30 days the amount of phosphatidylcholine had increased to about 20-fold, whereas the other phospholipid fractions had reached only an amount two or three times as great as in the control animals. The increase observed was steady for up to 90 days at the end of these experiments. The increase in lung phospholipids was far less when corundum was injected into the lungs.
74 - 77. 分别在气管内注射石英和刚玉后2至90天的大鼠肺脏中，对磷脂总量以及鞘磷脂、磷脂酰胆碱、磷脂酰丝氨酸和磷脂酰乙醇胺的含量进行了估算。石英导致肺脏总磷脂以及所检测的所有磷脂组分的含量显著增加。在应用石英后48小时便注意到了首次增加；30天后，磷脂酰胆碱的量增加到约20倍，而其他磷脂组分仅达到对照动物的两到三倍。在这些实验结束时，所观察到的增加在长达90天内保持稳定。当将刚玉注入肺脏时，肺磷脂的增加要少得多。
