前列腺素E1、E2和A2对犬后肢血管阻力以及对去甲肾上腺素、神经刺激和血管紧张素反应的影响。

The relationship between the vasodilator and inhibitory effects of prostaglandin E(1) (PGE(1)), E(2) and A(2) on responses to nerve stimulation, noradrenaline and angiotensin was evaluated in the dog hindlimb preparation.2. PGE(1) and PGE(2) were equipotent as vasodilators in the hindlimb; however, PGE(1) was much more potent as an inhibitor of vasoconstrictor responses to nerve stimulation, noradrenaline and angiotensin.3. PGA(2) and PGE(2) were approximately equal as inhibitors of vasoconstrictor responses to noradrenaline, nerve stimulation and angiotensin; however, PGE(2) was far more potent as a vasodilator.4. Since there is no relationship between the vasodilator and inhibitory effects of PGE(1), E(2) and A(2), and since the inhibitory effect of PGA(2) was present at a time when hindlimb perfusion pressure had returned to control value, it is concluded that the inhibitory action is probably not the result of a physiological antagonism.5. Since each prostaglandin inhibited responses to nerve stimulation and noradrenaline to approximately the same extent and responses to angiotensin were also inhibited, it is suggested that these agents antagonize vasoconstrictor responses by a nonspecific depressant effect on smooth muscle cells.

在犬后肢标本中评估了前列腺素E(1)（PGE(1)）、E(2)和A(2)的血管舒张作用与对神经刺激、去甲肾上腺素和血管紧张素反应的抑制作用之间的关系。
PGE(1)和PGE(2)作为后肢血管舒张剂的效力相当；然而，PGE(1)作为对神经刺激、去甲肾上腺素和血管紧张素引起的血管收缩反应的抑制剂，效力要强得多。
PGA(2)和PGE(2)作为对去甲肾上腺素、神经刺激和血管紧张素引起的血管收缩反应的抑制剂大致相当；然而，PGE(2)作为血管舒张剂的效力要强得多。
由于PGE(1)、E(2)和A(2)的血管舒张作用与抑制作用之间没有关系，并且由于当后肢灌注压恢复到对照值时PGA(2)的抑制作用仍然存在，因此得出结论，这种抑制作用可能不是生理性拮抗作用的结果。
由于每种前列腺素对神经刺激和去甲肾上腺素反应的抑制程度大致相同，并且对血管紧张素的反应也受到抑制，因此提示这些药物通过对平滑肌细胞的非特异性抑制作用来拮抗血管收缩反应。

Effect of prostaglandins E 1 , E 2 and A 2 on vascular resistance and responses to noradrenaline, nerve stimulation and angiotensin in the dog hindlimb.