Wade T R, Kopf A W, Ackerman A B
Arch Dermatol. 1979 Mar;115(3):306-8.
We report 34 cases of bowenoid papulosis of the genitalia. In each case, the patient had numerous reddish brown or violaceous papular lesions, some distinctly verrucoid, situated on the genitalia. Although clinically the lesions invariably appeared benign, histologic examination of specimens from the genital lesions in each patient showed changes of squamous cell carcinoma in situ. Many of the patients gave a history of preceding viral lesions on the genitalia. Therapy in all cases was conservative but thoroughly ablative. We view bowenoid papulosis as a new entity whose biologic behavior if untreated is as yet unknown.
我们报告了34例生殖器鲍温样丘疹病。每例患者生殖器部位均有大量红棕色或紫罗兰色丘疹性损害,部分损害明显呈疣状。尽管临床上这些损害始终表现为良性,但对每位患者生殖器损害标本进行组织学检查均显示原位鳞状细胞癌的改变。许多患者有生殖器部位先前病毒感染性损害的病史。所有病例的治疗均较为保守但彻底去除病灶。我们认为鲍温样丘疹病是一种新的疾病实体,若不治疗,其生物学行为尚不清楚。