Challacombe D N, Brown G A, Edkins S
Arch Dis Child. 1979 Feb;54(2):131-4. doi: 10.1136/adc.54.2.131.
Bile acids were estimated in the duodenum of infants with protracted diarrhoea and compared with those in a control group. Significantly lower levels of total bile acids were found in infants with protracted diarrhoea, a finding which may be due to ileal dysfunction. Low concentrations of total bile acids may contribute to the poor nutritional state of these patients by impairing the normal digestion and absorption of dietary fat and fat-soluble vitamins. The absence of deconjugated bile acids in the duodenal juice of most infants with protracted diarrhoea suggests that they do not contribute significantly to the pathophysiology of this disorder.
对患有迁延性腹泻的婴儿十二指肠中的胆汁酸进行了评估，并与对照组婴儿的胆汁酸进行了比较。发现患有迁延性腹泻的婴儿总胆汁酸水平显著较低，这一发现可能归因于回肠功能障碍。总胆汁酸浓度低可能通过损害膳食脂肪和脂溶性维生素的正常消化与吸收，导致这些患者营养状况不佳。大多数患有迁延性腹泻的婴儿十二指肠液中未检测到去结合胆汁酸，这表明它们对该疾病的病理生理过程贡献不大。
