双链核糖核酸在病毒感染动物中的毒性增加。
Increased toxicity of double-stranded ribonucleic acid in virus-infected animals.
作者信息
De Clercq E, Stewart W E, De Somer P
出版信息
Infect Immun. 1973 Feb;7(2):167-72. doi: 10.1128/iai.7.2.167-172.1973.
Virus-infected mice were significantly more susceptible to the toxic effects of double-stranded ribonucleic acid (RNA) than uninfected mice. A dramatic increase in mortality was observed after injection of either synthetic (polyriboinosinic.polyribocytidylic acid) or natural (mycophage) double-stranded RNA in mice infected with Newcastle disease virus (NDV) or vesicular stomatitis virus (VSV). With the exception of endotoxin, interferon inducers other than double-stranded RNA, such as tilorone-hydrochloride and chlorite-oxidized oxyamylose, did not show this increased toxicity in virus-infected animals. The increased susceptibility of virus-infected animals to the toxic effects of double-stranded RNA appears to be related to the levels of interferon induced by the virus infection, either systemically, in the blood stream (after inoculation of NDV), or locally, in the brain (after infection with VSV).
与未感染的小鼠相比，感染病毒的小鼠对双链核糖核酸（RNA）的毒性作用更敏感得多。在用新城疫病毒（NDV）或水泡性口炎病毒（VSV）感染的小鼠中，注射合成的（聚肌苷酸-聚胞苷酸）或天然的（噬菌体）双链RNA后，观察到死亡率急剧上升。除内毒素外，双链RNA以外的干扰素诱导剂，如盐酸泰洛龙和亚氯酸盐氧化直链淀粉，在病毒感染的动物中未显示出这种增加的毒性。病毒感染的动物对双链RNA毒性作用的易感性增加似乎与病毒感染诱导的干扰素水平有关，无论是全身性的，在血流中（接种NDV后），还是局部性的，在大脑中（感染VSV后）。
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