Thacore H R, Youngner J S
Infect Immun. 1973 May;7(5):685-90. doi: 10.1128/iai.7.5.685-690.1973.
When a continuous line of rabbit kidney cells (RK-13) was exposed to polyriboinosinic acid polyribocytidilic acid [poly(rI).poly(rC)], the cells became resistant to the replication of a ribonucleic acid (RNA) virus, vesicular stomatitis (VSV), but remained susceptible to the replication of two deoxyribonucleic acid (DNA) viruses, pseudorabies and vaccinia. These differences were identical to previous findings with RK-13 cells pretreated with exogenous rabbit interferon. Confirmation is thereby provided that RK-13 cells are deficient in the synthesis of resistance factors active against the DNA viruses tested and that there are separate resistance factors for RNA and DNA viruses in RK-13 cells. The resistance against VSV which developed in RK-13 cells exposed to poly(rI).poly(rC) could be significantly reversed by prior infection with infective vaccinia virus but not by vaccinia inactivated by ultraviolet irradiation or heat.
当兔肾细胞连续系（RK - 13）暴露于聚肌苷酸-聚胞苷酸[poly(rI).poly(rC)]时，这些细胞对一种核糖核酸（RNA）病毒——水疱性口炎病毒（VSV）的复制产生抗性，但对两种脱氧核糖核酸（DNA）病毒——伪狂犬病病毒和痘苗病毒的复制仍敏感。这些差异与先前用外源性兔干扰素预处理的RK - 13细胞的研究结果一致。由此证实，RK - 13细胞缺乏针对所测试的DNA病毒合成活性抗性因子的能力，并且RK - 13细胞中存在针对RNA病毒和DNA病毒的不同抗性因子。暴露于poly(rI).poly(rC)的RK - 13细胞中产生的对VSV的抗性，可通过先前感染有感染性的痘苗病毒而显著逆转，但不能通过紫外线照射或加热灭活的痘苗病毒逆转。
