感染反应低下：干扰素诱导剂治疗应用的潜在限制
Hyporeactivity of infection: potential limitation to therapeutic use of interferon-inducing agents.
作者信息
Stringfellow D A, Glasgow L A
出版信息
Infect Immun. 1972 Nov;6(5):743-7. doi: 10.1128/iai.6.5.743-747.1972.
Abstract
Interferon inducers are generally most effective as antiviral agents when used prophylactically. One possible explanation for this is that animals develop a state of hyporeactivity during the course of a virus infection. Such a progressive loss of capacity to produce interferon was observed with a representative group of interferon-inducing agents (polyinosinic-cytidylic acid, Tilorone hydrochloride, New-castle disease virus, or a strain of encephalomyocarditis virus) during the course of a model picornavirus infection in mice.
摘要
干扰素诱导剂在预防性使用时通常作为抗病毒剂最为有效。对此的一种可能解释是，动物在病毒感染过程中会出现反应性降低的状态。在小鼠的一种典型小核糖核酸病毒感染过程中，用一组具有代表性的干扰素诱导剂（聚肌苷酸 - 胞苷酸、盐酸泰洛龙、新城疫病毒或脑心肌炎病毒株）观察到了这种产生干扰素能力的逐渐丧失。
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