感染反应低下：干扰素诱导剂治疗应用的潜在限制
Hyporeactivity of infection: potential limitation to therapeutic use of interferon-inducing agents.
作者信息
Stringfellow D A, Glasgow L A
出版信息
Infect Immun. 1972 Nov;6(5):743-7. doi: 10.1128/iai.6.5.743-747.1972.
Abstract
Interferon inducers are generally most effective as antiviral agents when used prophylactically. One possible explanation for this is that animals develop a state of hyporeactivity during the course of a virus infection. Such a progressive loss of capacity to produce interferon was observed with a representative group of interferon-inducing agents (polyinosinic-cytidylic acid, Tilorone hydrochloride, New-castle disease virus, or a strain of encephalomyocarditis virus) during the course of a model picornavirus infection in mice.
摘要
干扰素诱导剂在预防性使用时通常作为抗病毒剂最为有效。对此的一种可能解释是，动物在病毒感染过程中会出现反应性降低的状态。在小鼠的一种典型小核糖核酸病毒感染过程中，用一组具有代表性的干扰素诱导剂（聚肌苷酸 - 胞苷酸、盐酸泰洛龙、新城疫病毒或脑心肌炎病毒株）观察到了这种产生干扰素能力的逐渐丧失。
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本文引用的文献
1
2
Virus interference. I. The interferon.病毒干扰。一、干扰素。
Proc R Soc Lond B Biol Sci. 1957 Sep 12;147(927):258-67. doi: 10.1098/rspb.1957.0048.
3
Kinetics of serum interferon response in mice after single and multiple injections of polyI-poly C.
Proc Soc Exp Biol Med. 1971 Feb;136(2):394-8. doi: 10.3181/00379727-136-35272.
4
Hong Kong influenza antigen sensitivity and decreased interferon response of peripheral lymphocytes.
Antimicrob Agents Chemother (Bethesda). 1970;10:156-60.
5
Inducers of interferon and host resistance. VI. Antiviral efficacy of poly I:C in animal models.干扰素与宿主抵抗力的诱导剂。VI. 聚肌胞苷酸在动物模型中的抗病毒功效。
Proc Soc Exp Biol Med. 1969 Nov;132(2):776-83. doi: 10.3181/00379727-132-34308.
6
Interferon appearance stimulated by endotoxin, bacteria, or viruses in mice pre-treated with Escherichia coli endotoxin or infected with Mycobacterium tuberculosis.在用大肠杆菌内毒素预处理或感染结核分枝杆菌的小鼠中，由内毒素、细菌或病毒刺激产生的干扰素。
Nature. 1965 Oct 30;208(5009):456-8. doi: 10.1038/208456a0.
7
Interferon induction and action.干扰素的诱导与作用。
Annu Rev Microbiol. 1971;25:333-60. doi: 10.1146/annurev.mi.25.100171.002001.
8
Current concepts of interferon and interferon induction.干扰素与干扰素诱导的当前概念
Annu Rev Med. 1970;21:17-46. doi: 10.1146/annurev.me.21.020170.000313.
9
Prospects for the use of double-stranded ribonucleic acid (poly I:C) inducers in man.
J Infect Dis. 1970 Feb;121(2):196-211. doi: 10.1093/infdis/121.2.196.
10
Polyinosinic-cytidylic acid complex (poly I:C) and viral infections in mice.聚肌苷酸-聚胞苷酸复合物（聚肌胞苷酸）与小鼠病毒感染
Proc Soc Exp Biol Med. 1969 Oct;132(1):83-7. doi: 10.3181/00379727-132-34153.
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