Dudley F J, O'Shea M J, Sherlock S
Clin Exp Immunol. 1973 Mar;13(3):367-72.
Sera from 134 HAA positive patients have been studied for the presence of a variety of autoantibodies. The patients were divided into groups dependent on the clinicopathological severity of the associated liver disease. Both smooth muscle antibody and rheumatoid factor were found in all groups of patients. However, their incidence and titre was higher in the groups of patients who had clinical and pathological evidence of the more active liver cell damage. As autoantibodies in viral infections may be an index of the presence of cell mediated immunity to the causative infective agent these results could support the hypothesis that cell mediated immunity is important in the pathogenesis of liver cell damage in HAA positive patients.
对134例乙肝表面抗原（HAA）阳性患者的血清进行了多种自身抗体检测。根据相关肝脏疾病的临床病理严重程度将患者分组。所有患者组中均发现了平滑肌抗体和类风湿因子。然而，在有更活跃肝细胞损伤临床和病理证据的患者组中，它们的发生率和滴度更高。由于病毒感染中的自身抗体可能是针对致病感染因子的细胞介导免疫存在的指标，这些结果可能支持细胞介导免疫在HAA阳性患者肝细胞损伤发病机制中起重要作用这一假说。
