糖尿病中的缺血后感觉异常
Post-ischaemic paraesthesiae in diabetes mellitus.
作者信息
Seneviratne K N, Senanayake N, Nimalasuriya A
出版信息
J Neurol Neurosurg Psychiatry. 1973 Apr;36(2):288-95. doi: 10.1136/jnnp.36.2.288.
A quantitative assessment of post-ischaemic paraesthesiae has been made in 50 diabetic subjects and in a group of healthy age-matched controls. The results show a highly significant diminution of the paraesthetic response in the diabetic subjects. The degree of depression of the paraesthetic response was associated with the duration of the disease and the severity of the metabolic abnormality as determined by the degree of insulin dependence. Diabetics with the juvenile onset type of the disease were more adversely affected than those with the maturity onset type. There was no consistent relationship between the degree of depression of the paraesthesiae and the presence of peripheral neuropathy. The significance of these results is discussed in relation to the factors which determine the composition of the ionic micro-environment of myelinated nerve and the level of electrical excitability of the nerve fibre.
对50名糖尿病患者和一组年龄匹配的健康对照者进行了缺血后感觉异常的定量评估。结果显示，糖尿病患者的感觉异常反应显著降低。感觉异常反应的抑制程度与疾病持续时间以及由胰岛素依赖程度所确定的代谢异常严重程度相关。青少年发病型糖尿病患者比成年发病型患者受到的负面影响更大。感觉异常的抑制程度与周围神经病变的存在之间没有一致的关系。结合决定有髓神经离子微环境组成和神经纤维电兴奋性水平的因素，对这些结果的意义进行了讨论。
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