Fetterman G H, Allison M E, Wilson C B, Gottschalk C W
Pathol Annu. 1978;13 Pt 1:55-79.
Microdissection revealed striking alterations in the nephrons of animal models AICN and anti-GBMN. The most severely damaged AICN kidney in the series presented marked heterogeneity in the size and deformity of the proximal tubules, corresponding to the diverse and variegated nephrons described by Oliver in chronic Bright's disease. The severely damaged anti-GBMN kidneys revealed widespread alterations in the proximal tubules, which, however, tended to be fairly uniform among the affected nephrons. This uniformity, perhaps, reflected the shorter duration of disease in the anti-GBMN animals. The most characteristic proximal tubular alteration in either the AICN or anti-GBMN animals was that combining atrophy of the pars convoluta and hypertrophy of the pars recta in same tubule. The largest and smallest nephrons encountered in the entire study were found in the most severly damaged kidney in the AICN. This finding reflected the simultaneous existence of regressive and progressive changes in this kidney, as certain nephrons underwent hypertrophy to compensate for the atrophy and disappearance of others. The remarkable functional glomerulotubular balance of single nephrons known to exist in both AICN and anti-GBMN was matched by the evidence presented here of structural glomerulotubular balance among the severely altered nephrons of a representative kidney from each group. Microdissection studies directed toward the characterization of the nephronic alterations in both membranous glomerulonephritis and proliferative glomerulonephritis of man should be of interest in relation to the findings in these experimental rat models of human disease.
显微解剖显示，动物模型AICN和抗GBMN的肾单位有显著改变。该系列中受损最严重的AICN肾脏，近端小管在大小和形态上存在明显的异质性，这与Oliver在慢性布赖特氏病中描述的多样且斑驳的肾单位相对应。受损严重的抗GBMN肾脏，近端小管出现广泛改变，不过，在受影响的肾单位中这些改变往往较为一致。这种一致性或许反映了抗GBMN动物疾病持续时间较短。AICN或抗GBMN动物中最具特征性的近端小管改变是同一小管中曲部萎缩而直部肥大。在整个研究中发现的最大和最小肾单位存在于AICN中受损最严重的肾脏。这一发现反映了该肾脏中退行性和进行性变化同时存在，因为某些肾单位发生肥大以补偿其他肾单位的萎缩和消失。已知AICN和抗GBMN中单个肾单位存在显著的功能性肾小球肾小管平衡，此处每组代表性肾脏中严重改变的肾单位之间存在结构性肾小球肾小管平衡的证据与之相符。针对人类膜性肾小球肾炎和增殖性肾小球肾炎中肾单位改变特征的显微解剖研究，对于这些人类疾病的实验大鼠模型的研究结果而言应该是有意义的。
