• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
A mutant transcription factor that is activated by 3':5'-cyclic guanosine monophosphate.一种由3':5'-环磷酸鸟苷激活的突变转录因子。
Proc Natl Acad Sci U S A. 1973 Apr;70(4):1017-21. doi: 10.1073/pnas.70.4.1017.
2
Cyclic adenosine monophosphate-independent mutants of the lactose operon of Escherichia coli.大肠杆菌乳糖操纵子的环磷酸腺苷非依赖性突变体。
J Bacteriol. 1973 May;114(2):652-5. doi: 10.1128/jb.114.2.652-655.1973.
3
Cyclic adenosine 5'-monophosphate in Escherichia coli.大肠杆菌中的环磷酸腺苷
Bacteriol Rev. 1976 Sep;40(3):527-51. doi: 10.1128/br.40.3.527-551.1976.
4
Genetic mapping of a new promoter for the lac operon.乳糖操纵子新启动子的遗传图谱分析。
J Mol Biol. 1975 Apr 5;93(2):311-7. doi: 10.1016/0022-2836(75)90134-5.
5
Theophylline inhibits the transcription of the lac operon in Escherichia coli.茶碱抑制大肠杆菌中乳糖操纵子的转录。
Acta Microbiol Acad Sci Hung. 1972;19(1):43-50.
6
Polycistronic effects of catabolite repression on the lac operon.分解代谢物阻遏对乳糖操纵子的多顺反子效应。
J Bacteriol. 1972 Dec;112(3):1184-92. doi: 10.1128/jb.112.3.1184-1192.1972.
7
Different cyclic AMP requirements for induction of the arabinose and lactose operons of Escherichia coli.大肠杆菌阿拉伯糖操纵子和乳糖操纵子诱导对环磷酸腺苷的不同需求。
J Mol Biol. 1973 Sep 5;79(1):149-62. doi: 10.1016/0022-2836(73)90276-3.
8
Regulation of the lactose operon in Escherichia coli by cAMP.环磷酸腺苷（cAMP）对大肠杆菌乳糖操纵子的调控
Int Rev Cytol. 1975;41:29-58. doi: 10.1016/s0074-7696(08)60965-1.
9
Studies with cyclic adenosine monophosphate receptor and stimulation of in vitro transcription of the Gal operon.关于环磷酸腺苷受体及对Gal操纵子体外转录刺激作用的研究。
J Biol Chem. 1974 Jun 10;249(11):3592-6.
10
Detection and isolation of the repressor protein for the tryptophan operon of Escherichia coli.大肠杆菌色氨酸操纵子阻遏蛋白的检测与分离
Proc Natl Acad Sci U S A. 1972 May;69(5):1100-3. doi: 10.1073/pnas.69.5.1100.

引用本文的文献

1
Mutations in the Global Transcription Factor CRP/CAP: Insights from Experimental Evolution and Deep Sequencing.全局转录因子CRP/CAP中的突变：来自实验进化和深度测序的见解
Comput Struct Biotechnol J. 2019 Jun 18;17:730-736. doi: 10.1016/j.csbj.2019.05.009. eCollection 2019.
2
Regulatory interactions among the cya, crp and pts gene products in Salmonella typhimurium.鼠伤寒沙门氏菌中cya、crp和pts基因产物之间的调控相互作用。
Mol Gen Genet. 1983;192(3):477-86. doi: 10.1007/BF00392194.
3
Isolation and characterization of cAMP suppressor mutants of Escherichia coli K12.大肠杆菌K12中环磷酸腺苷（cAMP）抑制突变体的分离与鉴定
Mol Gen Genet. 1981;182(3):480-9. doi: 10.1007/BF00293939.
4
Cyclic adenosine 3',5'-monophosphate-mediated hyperinduction of araBAD and lacZYA expression in a crp mutant of Escherichia coli K-12.环磷酸腺苷介导的大肠杆菌K-12 crp突变体中araBAD和lacZYA表达的超诱导
J Bacteriol. 1981 Aug;147(2):500-8. doi: 10.1128/jb.147.2.500-508.1981.
5
Suppression of defects in cyclic adenosine 3',5'-monophosphate metabolism in Escherichia coli.大肠杆菌中3',5'-环磷酸腺苷代谢缺陷的抑制
J Bacteriol. 1980 Oct;144(1):205-9. doi: 10.1128/jb.144.1.205-209.1980.
6
Phosphoenolpyruvate:carbohydrate phosphotransferase system of bacteria.细菌的磷酸烯醇式丙酮酸：糖磷酸转移酶系统
Microbiol Rev. 1985 Sep;49(3):232-69. doi: 10.1128/mr.49.3.232-269.1985.
7
Generation of deletions in the 3'-flanking sequences of the Escherichia coli crp gene that induce cyclic AMP suppressor functions.在大肠杆菌crp基因3'侧翼序列中产生缺失，这些缺失可诱导环磷酸腺苷抑制功能。
J Bacteriol. 1987 Feb;169(2):654-9. doi: 10.1128/jb.169.2.654-659.1987.
8
Indirect role of adenylate cyclase and cyclic AMP in chemotaxis to phosphotransferase system carbohydrates in Escherichia coli K-12.
J Bacteriol. 1987 Feb;169(2):593-9. doi: 10.1128/jb.169.2.593-599.1987.
9
Cloning and molecular characterization of csm mutations allowing expression of catabolite-repressible operons in the absence of exogenous cyclic AMP.在无外源环腺苷酸的情况下允许分解代谢物阻遏操纵子表达的csm突变体的克隆及分子特征分析
J Bacteriol. 1986 May;166(2):533-40. doi: 10.1128/jb.166.2.533-540.1986.
10
Mutations that alter the allosteric nature of cAMP receptor protein of Escherichia coli.改变大肠杆菌环磷酸腺苷受体蛋白变构性质的突变。
EMBO J. 1985 Dec 1;4(12):3329-32. doi: 10.1002/j.1460-2075.1985.tb04084.x.

本文引用的文献

1
Fusions of the lac and trp Regions of the Escherichia coli Chromosome.大肠杆菌染色体中乳糖操纵子和色氨酸操纵子区域的融合
J Bacteriol. 1970 Dec;104(3):1273-9. doi: 10.1128/jb.104.3.1273-1279.1970.
2
Genetic regulatory mechanisms in the synthesis of proteins.蛋白质合成中的遗传调控机制。
J Mol Biol. 1961 Jun;3:318-56. doi: 10.1016/s0022-2836(61)80072-7.
3
Transduction of linked genetic characters of the host by bacteriophage P1.噬菌体P1对宿主连锁遗传性状的转导
Virology. 1955 Jul;1(2):190-206. doi: 10.1016/0042-6822(55)90016-7.
4
Current linkage map of Escherichia coli.大肠杆菌当前的连锁图谱。
Bacteriol Rev. 1970 Jun;34(2):155-75. doi: 10.1128/br.34.2.155-175.1970.
5
Rapid bacteriophage sedimentation in the presence of polyethylene glycol and its application to large-scale virus purification.聚乙二醇存在下噬菌体的快速沉降及其在大规模病毒纯化中的应用
Virology. 1970 Mar;40(3):734-44. doi: 10.1016/0042-6822(70)90218-7.
6
Directed transposition of the arabinose operon: a technique for the isolation of specialized transducing bacteriophages for any Escherichia coli gene.阿拉伯糖操纵子的定向转座：一种用于分离针对任何大肠杆菌基因的特异性转导噬菌体的技术。
J Mol Biol. 1969 Aug 28;44(1):117-27. doi: 10.1016/0022-2836(69)90408-2.
7
A mechanism for repressor action.阻遏物作用机制。
J Mol Biol. 1969 Jul 14;43(1):201-13. doi: 10.1016/0022-2836(69)90089-8.
8
Mutagens which cause deletions in Escherichia coli.在大肠杆菌中引起缺失的诱变剂。
Genetics. 1969 Feb;61(2):371-6. doi: 10.1093/genetics/61.2.371.
9
The nature of mutants in the lac promoter region.乳糖操纵子启动子区域突变体的性质。
J Mol Biol. 1968 Dec;38(3):421-6. doi: 10.1016/0022-2836(68)90396-3.
10
Catabolite sensitive site of the lac operon.乳糖操纵子的分解代谢物敏感位点。
Nature. 1969 Mar 15;221(5185):1012-4. doi: 10.1038/2211012b0.

一种由3':5'-环磷酸鸟苷激活的突变转录因子。

A mutant transcription factor that is activated by 3':5'-cyclic guanosine monophosphate.

作者信息

Sanders R, McGeoch D

出版信息

Proc Natl Acad Sci U S A. 1973 Apr;70(4):1017-21. doi: 10.1073/pnas.70.4.1017.

DOI:10.1073/pnas.70.4.1017
PMID:4352217
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC433415/
Abstract

We report here the isolation of an extragenic suppressor of a promoter mutation in the lactose operon of Escherichia coli. Genetic data have indicated that the suppressor of the P(-) mutation maps in the structural gene for the transcription factor catabolite activator protein. Biochemical studies suggest that the mutant molecules of catabolite activator protein are altered in such a way that they are activated by 3':5'-cyclic GMP in addition to their normal effector, 3':5'-cyclic AMP.

摘要

我们在此报告从大肠杆菌乳糖操纵子的启动子突变中分离出一种基因外抑制子。遗传数据表明，P（-）突变的抑制子定位于转录因子分解代谢物激活蛋白的结构基因中。生化研究表明，分解代谢物激活蛋白的突变分子发生了改变，使得它们除了能被其正常效应物3':5'-环磷酸腺苷激活外，还能被3':5'-环磷酸鸟苷激活。