• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

人类视杆细胞中的卷积:一种衰老过程。

Convolution in human rods: an ageing process.

作者信息

Marshall J, Grindle J, Ansell P L, Borwein B

出版信息

Br J Ophthalmol. 1979 Mar;63(3):181-7. doi: 10.1136/bjo.63.3.181.

DOI:10.1136/bjo.63.3.181
PMID:435430
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1043437/
Abstract

In a morphological survey of 73 human retinae spanning 9 decades, and including 20 retinae which were obtained from eyes enucleated for malignant melanomas, nodular excrescences were noted in the outer segments of rods with an incidence which increased with age. These structures were sectioned in both their vertical and horizontal axes and on electron microscopical examination were seen to result from the localised convolution of affected outer segments. The topographic morphology of such convolutions is described and their modes of formation are discussed.

摘要

在一项对9个十年间的73例人类视网膜进行的形态学调查中,其中包括从因恶性黑色素瘤而摘除的眼球中获取的20例视网膜,发现视杆细胞外段存在结节状赘生物,其发生率随年龄增长而增加。这些结构在垂直和水平轴上都进行了切片,经电子显微镜检查发现,它们是由受影响的外段局部卷曲形成的。描述了这种卷曲的地形形态,并讨论了它们的形成方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88db/1043437/5ae48171269c/brjopthal00207-0046-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88db/1043437/43207c317961/brjopthal00207-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88db/1043437/c8c45c555d56/brjopthal00207-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88db/1043437/5ae48171269c/brjopthal00207-0046-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88db/1043437/43207c317961/brjopthal00207-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88db/1043437/c8c45c555d56/brjopthal00207-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88db/1043437/5ae48171269c/brjopthal00207-0046-a.jpg

相似文献

1
Convolution in human rods: an ageing process.人类视杆细胞中的卷积:一种衰老过程。
Br J Ophthalmol. 1979 Mar;63(3):181-7. doi: 10.1136/bjo.63.3.181.
2
Fusing human rod outer segments from an eye enucleated for choroidal melanoma.融合取自因脉络膜黑色素瘤而摘除眼球的人视杆外段。
Invest Ophthalmol Vis Sci. 1977 Jul;16(7):678-83.
3
Electron microscopy of three cases of choroid malignant melanomas.
Int Ophthalmol. 1987 Aug;10(4):193-202. doi: 10.1007/BF00155626.
4
The ageing photoreceptor.衰老的光感受器。
Vis Neurosci. 2007 Mar-Apr;24(2):151-5. doi: 10.1017/S0952523807070204.
5
The fenestrations of the choriocapillaris in the presence of choroidal melanoma.脉络膜黑色素瘤存在时脉络膜毛细血管的窗孔
Trans Am Ophthalmol Soc. 1982;80:498-516.
6
Benign melanoma of the choroid in a beagle: ophthalmological, light and electron microscopical investigations.
Vet Pathol. 1985 Nov;22(6):586-91. doi: 10.1177/030098588502200613.
7
Balloon cell malignant melanoma of the choroid: ultrastructural studies.脉络膜气球状细胞恶性黑色素瘤:超微结构研究
Br J Ophthalmol. 1983 Sep;67(9):579-84. doi: 10.1136/bjo.67.9.579.
8
[Histopathological study on the choroidal malignant melanoma. I. The mode of tumor invasion into the retinal pigment epithelial layer].脉络膜恶性黑色素瘤的组织病理学研究。I.肿瘤侵袭视网膜色素上皮层的方式
Nippon Ganka Gakkai Zasshi. 1985 Nov;89(11):1208-20.
9
Direct identification of T cells in malignant melanoma of the choroid.脉络膜恶性黑色素瘤中T细胞的直接鉴定
Int Ophthalmol Clin. 1980 Summer;20(2):93-102.
10
Electrondense cell inclusions of the human cone inner segments.人视锥细胞内节的电子致密细胞内含物。
Acta Ophthalmol (Copenh). 1991 Aug;69(4):491-5. doi: 10.1111/j.1755-3768.1991.tb02027.x.

引用本文的文献

1
Dissecting the biological complexity of age-related macular degeneration: Is it one disease, multiple separate diseases, or a spectrum?剖析年龄相关性黄斑变性的生物学复杂性:它是一种疾病、多种独立疾病,还是一个疾病谱?
Exp Eye Res. 2025 May;254:110304. doi: 10.1016/j.exer.2025.110304. Epub 2025 Feb 19.
2
Scavenging of Cation Radicals of the Visual Cycle Retinoids by Lutein, Zeaxanthin, Taurine, and Melanin.叶黄素、玉米黄质、牛磺酸和黑色素对视觉循环类视黄醇阳离子自由基的清除作用。
Int J Mol Sci. 2023 Dec 29;25(1):506. doi: 10.3390/ijms25010506.
3
Lipofuscin, Its Origin, Properties, and Contribution to Retinal Fluorescence as a Potential Biomarker of Oxidative Damage to the Retina.

本文引用的文献

1
DIFFERENCES IN MEMBRANE CONFIGURATION BETWEEN OSMIUM TETROXIDE-FIXED AND GLUTARALDEHYDE-FIXED CILIARY EPITHELIUM.四氧化锇固定和戊二醛固定的睫状上皮细胞膜结构的差异
J Cell Biol. 1964 Dec;23(3):658-64. doi: 10.1083/jcb.23.3.658.
2
Inherited retinal dystrophy in the rat.大鼠遗传性视网膜营养不良
J Cell Biol. 1962 Jul;14(1):73-109. doi: 10.1083/jcb.14.1.73.
3
Acid phosphatase activity in the retinal pigment epithelium.视网膜色素上皮中的酸性磷酸酶活性。
脂褐素,其起源、特性以及作为视网膜氧化损伤潜在生物标志物对视网膜荧光的贡献。
Antioxidants (Basel). 2023 Dec 13;12(12):2111. doi: 10.3390/antiox12122111.
4
Foveal Curvature and Its Associations in UK Biobank Participants.英国生物库参与者的中央凹曲率及其相关性。
Invest Ophthalmol Vis Sci. 2022 Jul 8;63(8):26. doi: 10.1167/iovs.63.8.26.
5
Is There an Optimal Combination of AREDS2 Antioxidants Zeaxanthin, Vitamin E and Vitamin C on Light-Induced Toxicity of Vitamin A Aldehyde to the Retina?年龄相关性眼病研究2(AREDS2)抗氧化剂玉米黄质、维生素E和维生素C对视黄醛光诱导视网膜毒性是否存在最佳组合?
Antioxidants (Basel). 2022 Jun 9;11(6):1132. doi: 10.3390/antiox11061132.
6
Photoreceptor Layer Thinning Is an Early Biomarker for Age-Related Macular Degeneration: Epidemiologic and Genetic Evidence from UK Biobank OCT Data.光感受器层变薄是年龄相关性黄斑变性的早期生物标志物:来自英国生物银行OCT数据的流行病学和遗传学证据。
Ophthalmology. 2022 Jun;129(6):694-707. doi: 10.1016/j.ophtha.2022.02.001. Epub 2022 Feb 8.
7
Pathogenic mechanisms contributing to the vulnerability of aging human photoreceptor cells.导致衰老人类光感受器细胞易损性的致病机制。
Eye (Lond). 2021 Nov;35(11):2917-2929. doi: 10.1038/s41433-021-01602-1. Epub 2021 Jun 2.
8
Changes in Retinal Structure and Ultrastructure in the Aged Mice Correlate With Differences in the Expression of Selected Retinal miRNAs.老年小鼠视网膜结构和超微结构的变化与所选视网膜微小RNA表达差异相关。
Front Pharmacol. 2021 Jan 13;11:593514. doi: 10.3389/fphar.2020.593514. eCollection 2020.
9
Modelling normal age-related changes in individual retinal layers using location-specific OCT analysis.利用特定部位 OCT 分析模型来模拟个体视网膜各层的正常年龄相关性变化。
Sci Rep. 2021 Jan 12;11(1):558. doi: 10.1038/s41598-020-79424-6.
10
Development of a Spatial Model of Age-Related Change in the Macular Ganglion Cell Layer to Predict Function From Structural Changes.开发一种黄斑神经节细胞层年龄相关性变化的空间模型,以预测结构变化与功能的关系。
Am J Ophthalmol. 2019 Dec;208:166-177. doi: 10.1016/j.ajo.2019.04.020. Epub 2019 May 10.
Vision Res. 1970 Sep;10(9):821-4. doi: 10.1016/0042-6989(70)90161-6.
4
The degradation of the photoreceptor outer segment within the pigment epithelial cell of rat retina.大鼠视网膜色素上皮细胞内光感受器外段的降解。
J Electron Microsc (Tokyo). 1970;19(1):85-99.
5
Retinal recovery from exposure to light.
Am J Ophthalmol. 1970 Aug;70(2):187-98. doi: 10.1016/0002-9394(70)90001-2.
6
Thermal and mechanical mechanisms in laser damage to the retina.激光致视网膜损伤的热机制和机械机制
Invest Ophthalmol. 1970 Feb;9(2):97-115.
7
Role of the retinal pigment epithelium in macular disease.视网膜色素上皮在黄斑疾病中的作用。
Trans Am Acad Ophthalmol Otolaryngol. 1972 Jan-Feb;76(1):64-80.
8
Shedding of discs from rod outer segments in the rhesus monkey.恒河猴视杆细胞外节中圆盘的脱落。
J Ultrastruct Res. 1971 Jan;34(1):190-203. doi: 10.1016/s0022-5320(71)90014-1.
9
An analysis of retinal receptor orientation. I. Angular relationship of neighboring photoreceptors.视网膜受体取向分析。I. 相邻光感受器的角度关系。
Invest Ophthalmol. 1971 Jan;10(1):69-77.
10
Experimental retinal detachment in the owl monkey. 3. Electron microscopy of retina and pigment epithelium.猫头鹰猴的实验性视网膜脱离。3. 视网膜和色素上皮的电子显微镜检查
Am J Ophthalmol. 1968 Sep;66(3):410-27. doi: 10.1016/0002-9394(68)91524-9.