Hoyt C S, Billson F A
Br J Ophthalmol. 1979 Mar;63(3):191-4. doi: 10.1136/bjo.63.3.191.
A symmetrical, bilateral optic neuropathy is reported in 2 patients being treated with ketogenic diets for seizure control. Laboratory tests suggested a thiamine deficiency, and both patients recovered normal visual function after several weeks of treatment with thiamine. The risk of optic nerve dysfunction occurring during the treatment with a ketogenic diet can be minimised if routine vitamin B supplements are given and periodic evaluation of optic nerve function undertaken.
报告了2例正在接受生酮饮食治疗以控制癫痫发作的患者出现对称性双侧视神经病变。实验室检查提示硫胺素缺乏,2例患者在接受硫胺素治疗数周后视觉功能恢复正常。如果给予常规维生素B补充剂并定期评估视神经功能,生酮饮食治疗期间发生视神经功能障碍的风险可以降至最低。