Chiswick M L, Ahmed A, Jack P M, Milner R D
Arch Dis Child. 1973 Sep;48(9):709-13. doi: 10.1136/adc.48.9.709.
In a series of experiments, one rabbit fetus of a litter was decapitated on day 24 of gestation and allowed to develop for a further 5 days. One effect of fetal decapitation was a reduction in the concentration of osmiophilic inclusion bodies in the type II pneumocytes of the lung. However, certain physical properties of the lung which depend on the presence of a surface active alveolar lining were normal. When 50 μg tetracosactrin was given to the fetus subcutaneously at the time of decapitation, there was no reduction in the concentration of inclusion bodies. It is suggested that though the production of surface active material in the pneumocyte is controlled at least in part by fetal adrenocortical hormones, the extrusion of this material into the alveolar space may be subject to other control. This may have important implications for the prophylactic treatment of the respiratory distress syndrome in premature babies by antepartum maternal glucocorticoid therapy.
在一系列实验中，一窝兔胎儿中的一只在妊娠第24天被断头，并使其再发育5天。胎儿断头的一个影响是肺Ⅱ型肺泡上皮细胞中嗜锇性包涵体浓度降低。然而，肺的某些依赖于表面活性肺泡内衬存在的物理特性是正常的。在断头时给胎儿皮下注射50μg二十四肽促皮质素，包涵体浓度没有降低。有人提出，虽然肺细胞中表面活性物质的产生至少部分受胎儿肾上腺皮质激素控制，但这种物质向肺泡腔的挤出可能受其他控制。这可能对产前母体糖皮质激素治疗早产婴儿呼吸窘迫综合征的预防性治疗具有重要意义。
