甲状腺激素对甲状腺切除大鼠肝脏酸性脂肪酶的影响及其被放线菌素D的抑制作用
Increase in liver acid lipase of thyroidectomized rats by thyroid hormones and its inhibition by actinomycin D.
作者信息
Coates P M, Lau H, Krulich L, Brown S A, Koldovsky O
出版信息
Biochim Biophys Acta. 1979 May 1;584(2):358-62. doi: 10.1016/0304-4165(79)90282-4.
PMID:435519
Abstract
Acid lipase activity in the livers of thyroidectomized rats is increased by administration of L-thyroxine. The response is dose-dependent and can be demonstrated within 12 h after treatment. L-Triiodothyronine also evokes a rapid increase in acid lipase activity, and this increase can be inhibited by coadministration of actinomycin D.
摘要
给予L-甲状腺素可增加甲状腺切除大鼠肝脏中的酸性脂肪酶活性。这种反应呈剂量依赖性，且在治疗后12小时内即可表现出来。L-三碘甲状腺原氨酸也可迅速引起酸性脂肪酶活性增加，且这种增加可被放线菌素D共同给药所抑制。
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