Drozhennikov V A, Perevezentseva O S, Orlova E B
Biokhimiia. 1979 Apr;44(4):649-57.
A developing Friend's viral leukemia is accompanied by a 2,0--2,5-fold increase in the activity of lysosomal DNAse (DNAse II) in mouse liver as compared to normal. The increase in activity is observed on the 10--12th day after inoculation of virus-containing material and reaches its maximum on the 20th post-inoculation day. The increase in DNAse II activity is due to activation of the lysosomal system of Kupffer's and endothelial cells of the liver. The activity of mitochondrial DNAse (DNAse I) in the livers of leukemic mice showed no deviations from the normal level. A possible role of DNAse II in the protective response of the organism is discussed.
一只患病毒性白血病的实验小鼠，其肝脏中溶酶体脱氧核糖核酸酶（脱氧核糖核酸酶II）的活性比正常小鼠高2.0至2.5倍。在接种含病毒物质后的第10至12天观察到活性增加，并在接种后的第20天达到最大值。脱氧核糖核酸酶II活性的增加是由于肝脏库普弗细胞和内皮细胞的溶酶体系统被激活。白血病小鼠肝脏中的线粒体脱氧核糖核酸酶（脱氧核糖核酸酶I）活性与正常水平无差异。文中讨论了脱氧核糖核酸酶II在机体保护反应中的可能作用。
