水泡性口炎病毒假型在对N-嗜性病毒具有抗性的细胞中与N-嗜性鼠白血病病毒包膜的生长情况。
Growth of pseudotypes of vesicular stomatitis virus with N-tropic murine leukemia virus coats in cells resistant to N-tropic viruses.
作者信息
Huang A S, Besmer P, Chu L, Baltimore D
出版信息
J Virol. 1973 Sep;12(3):659-62. doi: 10.1128/JVI.12.3.659-662.1973.
Abstract
Formation of pseudotypes between murine RNA tumor viruses and vesicular stomatitis virus (VSV) has been confirmed. Pseudotypes of VSV genomes coated by the surface envelope from an N-tropic tumor virus grew equally well in cells homozygous for either the Fv-1(n) or Fv-1(b) alleles. Therefore, the product of the Fv-1 locus, which restricts growth of murine RNA tumor viruses, must act on an intracellular aspect of tumor virus replication, a step after attachment and penetration.
摘要
鼠RNA肿瘤病毒与水泡性口炎病毒（VSV）之间假型的形成已得到证实。由N - 嗜性肿瘤病毒的表面包膜包裹的VSV基因组假型在Fv - 1(n)或Fv - 1(b)等位基因纯合的细胞中生长情况相同。因此，限制鼠RNA肿瘤病毒生长的Fv - 1基因座产物必定作用于肿瘤病毒复制的细胞内环节，即附着和穿透之后的步骤。
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