Serup J, Petersen S
Biol Neonate. 1979;35(3-4):175-9. doi: 10.1159/000241169.
A case of fetal thyrotoxicosis in utero in a boy with familial predisposition to thyrotoxicosis is reported. At 26 weeks of gestation fetal hyperkinesia and fetal tachycardia developed. This was preceded by a significant pathologic increase in long-acting thyroid stimulator (LATS) in the mother. The fetal hyperkinesia and tachycardia were considered to be signs of fetal thyrotoxicosis, possibly induced by placentally transferred LATS. The fetal thyrotoxicosis responded well to propylthiouracil given to the mother. After birth the boy developed slight signs of neonatal thyrotoxicosis although his serum thyroxine values increased analogous to those of his elder sister, who had presented classical neonatal thyrotoxicosis.
报道了一例患有甲状腺毒症家族易感性男孩的子宫内胎儿甲状腺毒症病例。妊娠26周时出现胎儿运动亢进和胎儿心动过速。在此之前，母亲体内长效甲状腺刺激素（LATS）出现显著病理性升高。胎儿运动亢进和心动过速被认为是胎儿甲状腺毒症的体征，可能是由胎盘转运的LATS诱发的。胎儿甲状腺毒症对给予母亲的丙硫氧嘧啶反应良好。出生后，该男孩出现了轻微的新生儿甲状腺毒症体征，尽管他的血清甲状腺素值升高情况与患有典型新生儿甲状腺毒症的姐姐类似。
