Maxwell K D, Kearney K K, Johnson J W, Eagan J W, Tyson J E
Obstet Gynecol. 1980 Mar;55(3 Suppl):18S-22S. doi: 10.1097/00006250-198003001-00006.
Tachycardia in both fetuses of a twin gestation was documented in a mother who had undergone subtotal thyroidectomy 8 years prior to her present pregnancy. Maternal and fetal plasma concentrations of long-acting thyroid stimulator (LATS) and amniotic fluid 3,3',5'-triiodothyronine (reverse T3) were determined. All values were consistent with the diagnosis of fetal thyrotoxicosis, as were cord blood studies performed on the fetuses post partum. Significant concentrations of LATS were present in fetal cord blood. The first fetus survived but suffered hyperthyroidism during the first 3 neonatal weeks. The second twin died, possibly of fetal thyrotoxicosis. These studies suggest that in women with a history of thyrotoxicosis, high levels of maternal LATS may in some instances provoke fetal thyrotoxicosis, which can be diagnosed by the measurement of amniotic fluid reverse T3.
一位在本次妊娠8年前接受过甲状腺次全切除术的母亲，其双胎妊娠的两个胎儿均出现心动过速。测定了母体和胎儿血浆中长效甲状腺刺激素（LATS）的浓度以及羊水3,3',5'-三碘甲状腺原氨酸（反三碘甲状腺原氨酸）的浓度。所有数值均与胎儿甲状腺毒症的诊断相符，产后对胎儿进行的脐血研究结果也是如此。胎儿脐血中存在显著浓度的LATS。第一个胎儿存活，但在出生后的前3周出现甲状腺功能亢进。第二个双胎儿死亡，可能死于胎儿甲状腺毒症。这些研究表明，有甲状腺毒症病史的女性，母体LATS水平升高在某些情况下可能引发胎儿甲状腺毒症，这可通过测定羊水反三碘甲状腺原氨酸来诊断。
