霍乱肠毒素对同种异体抗原免疫反应的体内抑制作用。
In vivo suppression of the immune response to alloantigen by cholera enterotoxin.
作者信息
Henney C S, Lichtenstein L M, Gillespie E, Rolley R T
出版信息
J Clin Invest. 1973 Nov;52(11):2853-7. doi: 10.1172/JCI107481.
Abstract
The immune response of C57BL/6 mice to allogeneic (DBA/2) mastocytoma cell suspensions was profoundly suppressed by intraperitoneal administration of 1 mug cholera enterotoxin 4 days after antigenic stimulation. The immune response assayed 11 days after antigen showed decreased cytolytically active thymusderived (T) lymphocytes and markedly depressed serumagglutinating titers. A comparable suppression of the immune response to skin allografts (DBA/2-->C57BL/6) was also effected by cholera toxin administration, although there was no prolongation of allograft survival. The mechanism of the immune suppression is apparently related to the known adenylate cyclase stimulatory activities of choleragen.
摘要
在抗原刺激4天后腹腔注射1微克霍乱肠毒素，可显著抑制C57BL/6小鼠对同种异体（DBA/2）肥大细胞瘤细胞悬液的免疫反应。抗原刺激11天后检测免疫反应，结果显示具有细胞溶解活性的胸腺来源（T）淋巴细胞减少，血清凝集效价显著降低。给予霍乱毒素也可对皮肤同种异体移植（DBA/2→C57BL/6）的免疫反应产生类似的抑制作用，尽管同种异体移植的存活时间没有延长。免疫抑制机制显然与已知的霍乱毒素腺苷酸环化酶刺激活性有关。
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