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[大鼠肝脏修复再生过程中的双核细胞]

[Binuclear cells in rat liver during repair regeneration of the organ].

作者信息

Beliaeva I D, Ivleva T S

出版信息

Biull Eksp Biol Med. 1979 Apr;87(4):347-9.

PMID:435627
Abstract

At early stages after partial hepatectomy (17 hours after the operation) binuclear cells become involved in proliferation in much lesser numbers, and 37 and 53 hours after the operation--in much greater numbers relative to their part in the population. New formation of binuclear cells (the presence of labeled binuclear cells 20 hours after the thymidine H3 administration) was the most intensive at the early regeneration stages (16--36 hours after the operation), when about 20% of mitoses are acytokinetic and lead to the formation of binuclear cells. At later periods only 8% of mitoses result in formation of binuclear cells.

摘要

在部分肝切除术后的早期阶段(术后17小时),双核细胞参与增殖的数量要少得多,而在术后37小时和53小时,相对于它们在细胞群体中的占比,参与增殖的数量要多得多。双核细胞的新形成(在给予H3胸苷20小时后出现标记的双核细胞)在早期再生阶段(术后16 - 36小时)最为活跃,此时约20%的有丝分裂是无胞质分裂的,并导致双核细胞的形成。在后期,只有8%的有丝分裂会导致双核细胞的形成。

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