Vorob'eva A A
Biull Eksp Biol Med. 1979 Apr;87(4):355-8.
The microvasculature (MV) of serous membranes was compared in rats with spontaneous genetic hypertension (SHR) and in normotensive Wistar rats. The study showed that in hypertension MV lesions had a systemic distribution, as structural changes were present in every MV component (arterioles, precapillaries, capillaries, postcapillaries, venules, lymphatic capillaries, and postcapillaries, nerve fibers); these lesions were generalized, as similar alterations could be found in all serous membranes studied. A close resemblance observed between MV of serous membranes in SHR and in patients who died of hypertensive disease confirms the concept suggesting the existence of MV changes which were relatively specific for hypertension, along with those of the nonspecific nature. Specificity of the hypertensive process is manifested in severe vascular lesions of a peculiar type, while the nonspecific phenomena are represented by a combination of intravascular, perivascular, and minimal vascular alterations represented by a universal MV response to various stresses.
对患有自发性遗传性高血压（SHR）的大鼠和血压正常的Wistar大鼠的浆膜微血管系统（MV）进行了比较。研究表明，在高血压状态下，MV病变呈全身性分布，因为每个MV组成部分（小动脉、毛细血管前微动脉、毛细血管、毛细血管后微静脉、小静脉、淋巴毛细血管以及神经纤维）均出现了结构变化；这些病变具有普遍性，因为在所有研究的浆膜中均可发现类似改变。在SHR大鼠的浆膜MV与死于高血压疾病的患者的浆膜MV之间观察到的密切相似性证实了这样一种概念，即除了存在非特异性性质的MV变化外，还存在相对特定于高血压的MV变化。高血压过程的特异性表现为特定类型的严重血管病变，而非特异性现象则表现为血管内、血管周围变化以及由MV对各种应激的普遍反应所代表的微小血管改变的组合。
