[Heterogeneity in the distribution of cytochrome P-450 in the liver lobule revealed on exposure to carbon tetrachloride].

A comparative study was made of cytochrome P-450 content and the histological pattern of the development and elimination of necrotic foci arising in the liver of CBA mice after inhalation of CCl4 vapour. Two hours after the inhalation the content of cytochrome P-450 was reduced by a factor of 1.7, and in 17, 24, and 48 hours--by a factor of 6. The necrotized area was about 40% of the total liver lobe area. It is supposed that the selective (CCl4) damage of the central lobe hepatocytes was related to the marked differences between the cytochrome P-450 content in different areas of the lobe.