Faktor V M, Uryvaeva I V, Kagan V E
Biull Eksp Biol Med. 1979 Apr;87(4):364-6.
A comparative study was made of cytochrome P-450 content and the histological pattern of the development and elimination of necrotic foci arising in the liver of CBA mice after inhalation of CCl4 vapour. Two hours after the inhalation the content of cytochrome P-450 was reduced by a factor of 1.7, and in 17, 24, and 48 hours--by a factor of 6. The necrotized area was about 40% of the total liver lobe area. It is supposed that the selective (CCl4) damage of the central lobe hepatocytes was related to the marked differences between the cytochrome P-450 content in different areas of the lobe.
对吸入四氯化碳蒸汽后CBA小鼠肝脏中细胞色素P - 450含量以及坏死灶形成和消除的组织学模式进行了比较研究。吸入两小时后，细胞色素P - 450含量降低了1.7倍，在17、24和48小时后降低了6倍。坏死面积约占肝叶总面积的40%。据推测，中央叶肝细胞的选择性（四氯化碳）损伤与叶不同区域细胞色素P - 450含量的显著差异有关。
