The metabolism of (ureyl-14C)tolbutamide in vitro and in vivo in man. - Suppr | 超能文献

The metabolism of (ureyl-14C)tolbutamide in vitro and in vivo in man.

作者信息

Darby F J, Grundy R K

出版信息

Life Sci. 1973 Jul 16;13(2):97-105. doi: 10.1016/0024-3205(73)90184-7.

DOI:10.1016/0024-3205(73)90184-7

Abstract

摘要

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The metabolism of (ureyl-14C)tolbutamide in vitro and in vivo in man.

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(Ureyl- 14 C) tolbutamide and (2- 14 C) pentobarbitone as substrates for the hepatic microsomal drug-metabolizing enzyme system in vitro.（脲基-14C）甲苯磺丁脲和（2-14C）戊巴比妥作为体外肝微粒体药物代谢酶系统的底物。

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Inhibition by ethylmorphine and pentobarbitone in vitro of the metabolism of (ureyl- 14 C)tolbutamide by hepatic microsomal preparations from sexually-immature male and female rats treated with phenobarbitone.用苯巴比妥处理的未成熟雄性和雌性大鼠的肝微粒体制剂在体外，乙基吗啡和戊巴比妥对（脲基-14C）甲苯磺丁脲代谢的抑制作用。

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