Bucknall R A, Swallow D L, Moores H, Harrad J
Nature. 1973 Nov 16;246(5429):144-5. doi: 10.1038/246144a0.
THE number and diversity of the viruses which infect the upper respiratory tract, and cause the common cold, virtually preclude the control of this disease by conventional vaccines. From this, apart from symptomatic therapy, the only hope for effective treatment of this most prevalent of diseases is in the development of broad spectrum antiviral drugs. We have developed a substituted guanidine, ICI 65,709 (ref. 1) (Fig. 1) which has good activity against all twenty-five rhinovirus serotypes tested in human embryonic lung cells, and also against certain other picornaviruses.
感染上呼吸道并引发普通感冒的病毒种类繁多，这实际上使得通过传统疫苗来控制这种疾病变得几乎不可能。因此，除了对症治疗外，有效治疗这种最常见疾病的唯一希望在于开发广谱抗病毒药物。我们已经研发出一种取代胍，即ICI 65,709（参考文献1）（图1），它对在人胚肺细胞中测试的所有25种鼻病毒血清型都具有良好的活性，并且对某些其他小核糖核酸病毒也有活性。
