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强直和强直后增强对青蛙神经肌肉接头处递质释放易化的影响。

The effect of tetanic and post-tetanic potentiation on facilitation of transmitter release at the frog neuromuscular junction.

作者信息

Magleby K L

出版信息

J Physiol. 1973 Oct;234(2):353-71. doi: 10.1113/jphysiol.1973.sp010349.

Abstract
  1. End-plate potentials (e.p.p.s) were recorded from frog neuromuscular junctions blocked with high Mg and/or low Ca.2. Estimates of f(t), the facilitation contributed by each impulse, were obtained during and following repetitive stimulation from the incremental change in e.p.p. amplitudes following step changes in the stimulation rate during the conditioning and testing trains.3. Estimates of f(t) increased during the conditioning stimulation and returned to control in the post-tetanic period. This increase in f(t) was proportional to the magnitude of tetanic or post-tetanic potentiation (PTP) present.4. These results are described by: [Formula: see text] where h(t)/h(c) is the e.p.p. amplitude at time t expressed in terms of the control, P(t) is potentiation, F(t) is facilitation and 1 is the base level of transmitter release. Thus, potentiation has a multiplicative (gain) effect on facilitation and the base level of transmitter release.5. PTP was present immediately following the conditioning train. However, if depression occurred during the conditioning train, PTP developed after a delay.6. It is suggested that facilitation and potentiation represent increases in two independent factors which act jointly to increase the probability of transmitter release.
摘要
  1. 终板电位(e.p.p.s)是从用高镁和/或低钙阻断的青蛙神经肌肉接头处记录的。

  2. f(t)的估计值,即每个冲动产生的易化作用,是在重复刺激期间及之后,根据条件刺激和测试刺激序列中刺激速率阶跃变化后e.p.p.幅度的增量变化获得的。

  3. f(t)的估计值在条件刺激期间增加,并在强直后时期恢复到对照水平。f(t)的这种增加与存在的强直或强直后增强(PTP)的幅度成比例。

  4. 这些结果由以下公式描述:[公式:见原文],其中h(t)/h(c)是以对照表示的时间t时的e.p.p.幅度,P(t)是增强,F(t)是易化,1是递质释放的基础水平。因此,增强对易化和递质释放的基础水平具有乘法(增益)效应。

  5. 在条件刺激序列之后立即出现PTP。然而,如果在条件刺激序列期间出现抑制,则PTP会延迟出现。

  6. 有人提出,易化和增强代表两个独立因素的增加,它们共同作用以增加递质释放的概率。

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本文引用的文献

5
Quantal components of the end-plate potential.终板电位的量子成分。
J Physiol. 1954 Jun 28;124(3):560-73. doi: 10.1113/jphysiol.1954.sp005129.
10
Analysis of mobilization and demobilization processes in neuromuscular transmission in the frog.
J Neurophysiol. 1969 Sep;32(5):793-800. doi: 10.1152/jn.1969.32.5.793.

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