与人类成纤维细胞杂交后，L细胞中鲨烯醇向胆固醇转化的恢复。
Restoration of the conversion of desmosterol to cholesterol in L-cells after hybridization with human fibroblasts.
作者信息
Croce C M, Kieba I, Koprowski H, Molino M, Rothblat G H
出版信息
Proc Natl Acad Sci U S A. 1974 Jan;71(1):110-3. doi: 10.1073/pnas.71.1.110.
Hybrids between different human cells (which synthesize cholesterol) and mouse cells (whose end-product of sterol synthesis is desmosterol) were analyzed for the ability to convert desmosterol to cholesterol. Conversion of [(14)C]desmosterol to cholesterol and incorporation of [(14)C]acetate into the end-product sterol were studied in the parental and hybrid cells. Concordant segregation of the conversion of desmosterol to cholesterol and the human chromosome F-20 was observed.
对不同人类细胞（合成胆固醇）与小鼠细胞（其甾醇合成的终产物是胆甾烯醇）之间的杂交细胞进行分析，以研究其将胆甾烯醇转化为胆固醇的能力。在亲本细胞和杂交细胞中研究了[（14）C]胆甾烯醇向胆固醇的转化以及[（14）C]乙酸盐掺入终产物甾醇的情况。观察到胆甾烯醇向胆固醇的转化与人类染色体F - 20的一致分离。
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