小鼠腹腔巨噬细胞与猿猴病毒40转化的人细胞之间的体细胞杂种：II. 杂种细胞诱导的肿瘤细胞中携带猿猴病毒40基因组的人染色体7的存在情况。
Somatic cell hybrids between mouse peritoneal macrophages and simian-virus-40-transformed human cells: II. Presence of human chromosome 7 carrying simin virus 40 genome in cells of tumors induced by hybrid cells.
作者信息
Croce C M, Aden D, Koprowski H
出版信息
Proc Natl Acad Sci U S A. 1975 Apr;72(4):1397-400. doi: 10.1073/pnas.72.4.1397.
Abstract
Cells derived from tumors induced in "nude" mice after injection of cells that were hybrids between mouse peritoneal macrophages and simian virus 40 (SV40)-transformed human cells were found to retain the human chromosome 7 carrying the SV40 genome, and indicate that the presence of human chromosome 7 carrying the SV40 genome is responsible for the expression of the tumorigenic phenotype in the hybrid cells.
摘要
在将小鼠腹膜巨噬细胞与猿猴病毒40（SV40）转化的人类细胞杂交后的细胞注射到“裸”鼠体内诱导产生肿瘤，从这些肿瘤中获得的细胞被发现保留了携带SV40基因组的人类7号染色体，这表明携带SV40基因组的人类7号染色体的存在是杂交细胞中致瘤表型表达的原因。
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