Albarracín I, Lassaga F E, Caputto R
J Lipid Res. 1974 Jan;15(1):89-93.
Comparison of the skeletal muscles from vitamin E-deficient and control rabbits showed that the muscles from the deficient animals had lower contents of protein and glycogen but more water and lipid. Increases of individual lipids per unit weight of muscle from deficient animals compared with those from control animals were 2.2-fold for gangliosides, 2.18-fold for cholesterol, 1.74-fold for sulfatides, and 1.45-fold for neutral glycosylceramides. Total phospholipids did not change; this was the result of an increase in sphingomyelin (1.47-fold) and a decrease of phosphatidylcholine to 83% of the control, while the other fractions remained unchanged. When the measurements were referred to total muscle, the contents of cholesterol, gangliosides, sulfatides, neutral glycosylceramides, and sphingomyelin in muscle from vitamin E-deficient rabbits were also above those of the control rabbits, and only the phosphatidylcholine content was decreased. It was not possible to determine whether the alteration of lipid content preceded or followed the onset of signs of muscular dystrophy.
对维生素E缺乏的兔子和对照兔子的骨骼肌进行比较发现，缺乏维生素E的动物的肌肉中蛋白质和糖原含量较低，但水分和脂质含量较高。与对照动物相比，缺乏维生素E的动物每单位肌肉重量中个别脂质的增加倍数为：神经节苷脂2.2倍、胆固醇2.18倍、硫脂1.74倍、中性糖基神经酰胺1.45倍。总磷脂没有变化；这是鞘磷脂增加（1.47倍）以及磷脂酰胆碱降至对照的83%的结果，而其他组分保持不变。当测量结果以总肌肉量为参照时，维生素E缺乏的兔子肌肉中的胆固醇、神经节苷脂、硫脂、中性糖基神经酰胺和鞘磷脂含量也高于对照兔子，只有磷脂酰胆碱含量降低。无法确定脂质含量的改变是在肌肉萎缩迹象出现之前还是之后发生。
